*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : MF3240000
CHEMICAL NAME : Guanidine, (2-(hexahydro-1(2H)-azocinyl)ethyl)-,
sulfate (2:1)
CAS REGISTRY NUMBER : 60-02-6
LAST UPDATED : 199612
DATA ITEMS CITED : 11
MOLECULAR FORMULA : C20-H44-N8.H2-O4-S
MOLECULAR WEIGHT : 494.80
WISWESSER LINE NOTATION : T8NTJ A2MYZUM & 2WSQQ
COMPOUND DESCRIPTOR : Drug
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* beta-1-Azacyclooctylethylguanidine sulfate
* Azocine, 1-(2-guanidinoethyl)octahydro-, sulfate (2:1)
* Guanethidine bisulfate
* Guanethidine sulfate
* Guanetidin sulfate
* Guanidine, (2-(hexahydro-1(2H)-azocinyl)ethyl)-, sulfate
* Guanidine, (2-(octahydro-1-azocinyl)ethyl)-, sulfate (2:1)
* (2-(Hexahydro-1(2H)-azocinyl)ethyl)guanidine sulfate
* Ismelin sulfate
* Isobarin
* NSC-29863
* Octadin
* Octadine
* (2-(Octahydro-1-azocinyl)ethyl)guanidine sulfate
* Octatensin
* Oktadin
* Sanotensin
* SU-5864
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 128,22,1960
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 23 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 128,22,1960
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
URXXAF U.S.S.R. Patent Document. (Gosudarstvennyi Komitet SSSR po Delam
Izobretenii i Otkrytii, Malyi Tcherkasski pereulok 2/6, Moscow, Russia).
Volume(issue)/page/year: #0822829
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 112 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
URXXAF U.S.S.R. Patent Document. (Gosudarstvennyi Komitet SSSR po Delam
Izobretenii i Otkrytii, Malyi Tcherkasski pereulok 2/6, Moscow, Russia).
Volume(issue)/page/year: #0822829
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 278 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
URXXAF U.S.S.R. Patent Document. (Gosudarstvennyi Komitet SSSR po Delam
Izobretenii i Otkrytii, Malyi Tcherkasski pereulok 2/6, Moscow, Russia).
Volume(issue)/page/year: #0822829
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 18 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010)
Volume(issue)/page/year: NX#08547
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 3680 mg/kg/92D-I
TOXIC EFFECTS :
Peripheral Nerve and Sensation - structural change in nerve or sheath
Vascular - BP lowering not characterized in autonomic section
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
41,209,1977
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Human - man
DOSE : 391 mg/kg
SEX/DURATION : male 78 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - other effects on male
Reproductive - Fertility - male fertility index (e.g. # males impregnating
females per # males exposed to fertile nonpregnant females)
REFERENCE :
JSXRAJ Journal of Sex Research. (Soc. for the Scientific Study of Sex,
Inc., Mt. Royal & Guilford Aves., Baltimore, MD 21202) V.1- 1965-
Volume(issue)/page/year: 3,69,1967
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rat
DOSE : 1400 mg/kg
SEX/DURATION : male 56 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - other effects on male
Reproductive - Fertility - male fertility index (e.g. # males impregnating
females per # males exposed to fertile nonpregnant females)
REFERENCE :
BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.34- 1968- Volume(issue)/page/year:
48,30,1973
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Rodent - rat
DOSE : 900 mg/kg
SEX/DURATION : female 14 day(s) pre-mating
female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - other postnatal measures or effects
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
Volume(issue)/page/year: 56,715,1979
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X6127
No. of Facilities: 89 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 2323 (estimated)
No. of Female Employees: 1200 (estimated)
*** END OF RECORD ***