*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AU1578000
CHEMICAL NAME           : Actinomycin D, 2(sup A)-D-alloisoleucine-2(sup
                          B)-D-alloisoleucine-3(sup A)-(N- methylglycine)-3(sup
                          B)-(N-methylglycine)-
CAS REGISTRY NUMBER     : 1402-46-6
LAST UPDATED            : 198211
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C60-H86-N12-O16
MOLECULAR WEIGHT        : 1231.58
COMPOUND DESCRIPTOR     : Drug
                          Natural Product
SYNONYMS/TRADE NAMES :
   * Actinomycin F3
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 5 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- ,  Berdy, J., Boca
   Raton, FL, CRC Press, 1980-  Volume(issue)/page/year: 4(2),65,1980
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   38KLAC "Structure-Activity Relationship among the Semisynthetic
   Antibiotics,"  Perlman, D., ed., New York, Academic Press, 1977
   Volume(issue)/page/year: -,427,1977
 
                            *** END OF RECORD ***