*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AT6900000
CHEMICAL NAME           : Acrylonitrile, 2-(p-methoxyphenyl)-3,3-diphenyl-
CAS REGISTRY NUMBER     : 16143-89-8
BEILSTEIN REFERENCE NO. : 2814176
REFERENCE               : 3-10-00-01337 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C22-H17-N-O
MOLECULAR WEIGHT        : 311.40
WISWESSER LINE NOTATION : 1OR DYCN&UYR&R
COMPOUND DESCRIPTOR     : Tumorigen
SYNONYMS/TRADE NAMES :
   * alpha-(p-Methoxyphenyl)-beta,beta-diphenylacrylonitrile
   * 2-(p-Methoxyphenyl)-3,3-diphenylacrylonitrile
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 94 mg/kg/26W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Blood - lymphoma, including Hodgkin's disease
REFERENCE :
   MMJJAI Mie Medical Journal.  (Mie Univ. of Medicine, Tsu 514, Japan)  V.3-
   1952-  Volume(issue)/page/year: 11,95,1961
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 320 mg/kg/1Y-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Blood - lymphoma, including Hodgkin's disease
   Skin and Appendages - tumors
REFERENCE :
   NNGZAZ Nippon Naibumpi Gakkai Zasshi.  Journal of the Japan Endocrine
   Society.  (Nippon Naibumpi Gakkai, c/o Kyoto-Furitsu Ika Daigaku, Kojinbashi
   Nishizume-Sagaru, Kamigyo-ku, Kyoto 602, Japan)  V.1-    1925-
   Volume(issue)/page/year: 33,53,1957
 
                            *** END OF RECORD ***