*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AR9100000
CHEMICAL NAME           : Acridine, 9-(p-dimethylaminoanilino)-
CAS REGISTRY NUMBER     : 13365-38-3
BEILSTEIN REFERENCE NO. : 0487364
LAST UPDATED            : 199612
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C21-H19-N3
MOLECULAR WEIGHT        : 313.43
WISWESSER LINE NOTATION : T C666 BNJ IMR DN1&1
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Acridine, 9-((p-(dimethylamino)phenyl)amino)-
   * N'-9-Acridinyl-N,N-dimethyl-1,4-benzenediamine
   * 1,4-Benzenediamine, N'-9-acridinyl-N,N-dimethyl-
   * 9-(p-Dimethylaminoanilino)acridine
   * 9-((p-(Dimethylamino)phenyl)amino)acridine
   * NSC 13002
   * WIN 1701
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 15 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCIAL* Progress Report Submitted to the National Cancer Institute by Arthur
   D. Little, Inc. (15 Acorn Park, Cambridge, MA 02140)
   Volume(issue)/page/year: -,326,1967
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 80970 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCISP* National Cancer Institute Screening Program Data Summary,
   Developmental Therapeutics Program. (Bethesda, MD 20205)
   Volume(issue)/page/year: JAN1986
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 5 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
   Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
   NCIAL* Progress Report Submitted to the National Cancer Institute by Arthur
   D. Little, Inc. (15 Acorn Park, Cambridge, MA 02140)
   Volume(issue)/page/year: -,326,1967
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 5 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Behavioral - convulsions or effect on seizure threshold
   Cardiac - pulse rate
REFERENCE :
   NCIAL* Progress Report Submitted to the National Cancer Institute by Arthur
   D. Little, Inc. (15 Acorn Park, Cambridge, MA 02140)
   Volume(issue)/page/year: -,326,1967
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 35 mg/kg/28D-I
TOXIC EFFECTS :
   Cardiac - arrhythmias (including changes in conduction)
   Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis)
   Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
   NCIAL* Progress Report Submitted to the National Cancer Institute by Arthur
   D. Little, Inc. (15 Acorn Park, Cambridge, MA 02140)
   Volume(issue)/page/year: -,326,1967
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 35 mg/kg/28D-I
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis)
   Gastrointestinal - changes in structure or function of salivary glands
   Blood - pigmented or nucleated red blood cells
REFERENCE :
   NCIAL* Progress Report Submitted to the National Cancer Institute by Arthur
   D. Little, Inc. (15 Acorn Park, Cambridge, MA 02140)
   Volume(issue)/page/year: -,326,1967
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA damage
TEST SYSTEM             : Mammal - species unspecified Lymphocyte
DOSE/DURATION           : 2 umol/L
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 24,170,1981
 
                            *** END OF RECORD ***