*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AR8050000
CHEMICAL NAME           : Acridine,
                          9-(2-((2-chloroethyl)amino)ethylamino)-6-chloro-2-met
                          hoxy-, dihydrochloride, hydrate
CAS REGISTRY NUMBER     : 10072-24-9
LAST UPDATED            : 199304
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C18-H19-Cl2-N3-O.2Cl-H.H2-O
MOLECULAR WEIGHT        : 454.23
WISWESSER LINE NOTATION : T C666 BNJ EG IM2M2G LO1 &GH 2 &QH 2
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * 9-(2-((2-Chloroethyl)amino)ethylamino)-6-chloro-2-methoxyacridine,  
   dihydrochloride
   * ICR-125
   * Quinacrine ethyl M/2
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 570 mg/kg/4W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   36,915,1966

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: CHO gene mutation

 
                            *** END OF RECORD ***