*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AR7876000
CHEMICAL NAME           : Acridine,
                          6-chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-
                          methoxy-, dihydrochloride, dihydrate
CAS REGISTRY NUMBER     : 6151-30-0
LAST UPDATED            : 199112
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C23-H30-Cl-N3-O.2Cl-H.2H2-O
MOLECULAR WEIGHT        : 507.96
COMPOUND DESCRIPTOR     : Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Atabrine hydrochloride dihydrate
   * 6-Chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-methoxyacridine  
   dihydrochloride 2H2-O
   * Mepacrine hydrochloride dihydrate
   * Quinacrine dihydrochloride dihydrate
   * Quinacrine hydrochloride dihydrate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 37 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   44,225,1978
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intratesticular
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 4 mg/kg
SEX/DURATION            : male 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
   CCPTAY Contraception.  (Geron-X, Inc., POB 1108, Los Altos, CA 94022)  V.1-
   1970-  Volume(issue)/page/year: 6,329,1972
 
                            *** END OF RECORD ***