*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AR7580000
CHEMICAL NAME           : Acridine,
                          9-(4-bis(2-chloroethyl)amino-1-methylbutylamino)-6-ch
                          loro-2-methoxy-, dihydrochloride
CAS REGISTRY NUMBER     : 4213-45-0
LAST UPDATED            : 199710
DATA ITEMS CITED        : 15
MOLECULAR FORMULA       : C23-H28-Cl3-N3-O.2Cl-H
MOLECULAR WEIGHT        : 541.81
WISWESSER LINE NOTATION : T C666 BNJ EG IMY3N2G2G LO1 &GH &GH
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   *   9-(4-Bis(2-chloroethyl)amino-1-methylbutylamino)-6-chloro-2-methoxyacrid
     ine dihydrochloride
   * ICR 10
   *   2-Methoxy-6-chloro-9-(4-bis(2-chloroethyl)amino-1-methylbutylamino)acrid
     ine dihydrochloride
   * 2-Methoxy-6-chloro-9-(3-(ethyl-2-chloroethyl)aminopropylamino)acridine  
   dihydrochloride
   * 1,4-Pentanediamine,  
   N',N'-bis(2-chloroethyl)-N4-(6-chloro-2-methoxy-9-acridinyl)-, 2HCl
   * Quinacrine mustard dihydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2700 ug/kg
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   36,2423,1976
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 10 ug/plate
REFERENCE :
   PNASA6 Proceedings of the National Academy of Sciences of the United States
   of America.  (National Academy of Sciences, Printing & Pub. Office, 2101
   Constitution Ave., Washington, DC 20418) V.1-    1915-
   Volume(issue)/page/year: 72,5135,1975
 
TYPE OF TEST            : Specific locus test
ROUTE OF EXPOSURE       : Parenteral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 2 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 1,437,1964
 
TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Parenteral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 2 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 1,437,1964
 
TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 1 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 30,273,1975
 
TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 50 umol/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 26,553,1974

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: D melanogaster-whole sex chrom. loss
   
   EPA GENETOX PROGRAM 1988, Positive: D melanogaster-partial sex chrom. loss
   
   EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
   
   EPA GENETOX PROGRAM 1988, Positive: In vitro SCE-human lymphocytes; In vitro
   SCE-human
   
   EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro SCE-nonhuman
   
   EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-reciprocal
   translocation
   
   EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus
   
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***