*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : LZ5250000
CHEMICAL NAME           : Gluconic acid, compd. with quinidine (1:1), D-
CAS REGISTRY NUMBER     : 7054-25-3
OTHER CAS REGISTRY NOS. : 29826-49-1
LAST UPDATED            : 199506
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C20-H24-N2-O2.C6-H12-O7
MOLECULAR WEIGHT        : 520.64
WISWESSER LINE NOTATION : T66 BNJ HO1 EYQ- DT66 A B CNTJ A1U1 &QVYQYQYQYQ1Q
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * Cinchonan-9-ol, 6'-methoxy-, (9S)-, mono-D-gluconate (salt)
   * Quinaglute
   * Quinidine gluconate
   * Quinidine, D-gluconate (salt)
   * Quinidine mono-D-gluconate (salt)
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 7609 mg/kg/78W-I
TOXIC EFFECTS :
   Skin and Appendages - dermatitis, allergic (after systemic exposure)
REFERENCE :
   AIMDAP Archives of Internal Medicine.  (AMA, 535 N. Dearborn St., Chicago,
   IL 60610)  V.1-    1908-  Volume(issue)/page/year: 145,446,1985
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 337 mg/kg/17D-I
TOXIC EFFECTS :
   Blood - changes in cell count (unspecified)
   Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
   AJMEAZ American Journal of Medicine.  (Technical Pub., 875 Third Ave., New
   York, NY 10022) V.1-    1946-  Volume(issue)/page/year: 77,345,1984
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   23,288,1972

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 83945
       No. of Facilities: 33 (estimated)
       No. of Industries: 1
       No. of Occupations: 1
       No. of Employees: 66 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 83945
       No. of Facilities: 63 (estimated)
       No. of Industries: 1
       No. of Occupations: 3
       No. of Employees: 9094 (estimated)
       No. of Female Employees: 8028 (estimated)

 
                            *** END OF RECORD ***