*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MA2275050
CHEMICAL NAME           : Glutaminase, L-
CAS REGISTRY NUMBER     : 9001-47-2
LAST UPDATED            : 199512
DATA ITEMS CITED        : 2
SYNONYMS/TRADE NAMES :
   * E.C. 3.5.1.2
   * L-Glutaminase
   * Glutamine aminohydrolase
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 320 iu/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   POKLA8 Problemi na Onkologiyata.  Problems of Oncology.  (Durzhavno
   Izdatel'stvo Meditsina i Fizkultura, Pl. Slaveikov 11, Sofia, Bulgaria) V.1-
      1973-  Volume(issue)/page/year: 9,75,1981
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 4500 iu/kg/3D-I
TOXIC EFFECTS :
   Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - phosphatases
   Related to Chronic Data - death
REFERENCE :
   BJEPA5 British Journal of Experimental Pathology.  (Blackwell Scientific
   Pub. Ltd., POB 88, Oxford, UK)  V.1-    1920-  Volume(issue)/page/year:
   61,208,1980
 
                            *** END OF RECORD ***