*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MA1232000
CHEMICAL NAME           : Glutamic acid,
                          N-(p-(((2,4-diamino-6-pteridinyl)methyl)methylamino)b
                          enzoyl)-, disodium salt, L-(+)-
CAS REGISTRY NUMBER     : 7413-34-5
LAST UPDATED            : 199504
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C20-H20-N8-O5.2Na
MOLECULAR WEIGHT        : 498.46
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Amethopterin sodium
   * 4-Amino-N(sup 10)-methylpteroylglutamic acid disodium salt
   * Disodium methotrexate
   * Methotrexate disodium salt
   * MTX disodium
   * Sodium methotrexate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 284 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   58,735,1977
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 120 mg/kg
SEX/DURATION            : male 60 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
   Reproductive - Fertility - male fertility index (e.g. # males impregnating
   females per # males exposed to fertile nonpregnant females)
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   58,735,1977

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X5643
       No. of Facilities: 4 (estimated)
       No. of Industries: 1
       No. of Occupations: 15
       No. of Employees: 1233 (estimated)

 
                            *** END OF RECORD ***