*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MA1224000
CHEMICAL NAME           : Glutamic acid,
                          N-(p-(((2,4-diamino-6-pteridinyl)methyl)methylamino)b
                          enzoyl)-, D-
CAS REGISTRY NUMBER     : 51865-79-3
LAST UPDATED            : 199610
DATA ITEMS CITED        : 1
MOLECULAR FORMULA       : C20-H22-N8-O5
MOLECULAR WEIGHT        : 454.50
WISWESSER LINE NOTATION : T66 BN DN GN JNJ CZ EZ H1N1&R DVMYVQ2VQ -D
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * D-Amethopterin
   * N-(4-(((2,4-Diamino-6-pteridinyl)methyl)methylamino)benzoyl)-D-glutamic  
   acid
   * D-Methotrexate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 18 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NEOLA4 Neoplasma.  (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland) V.4-
      1957-  Volume(issue)/page/year: 29,43,1982
 
                            *** END OF RECORD ***