*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : LZ4370000
CHEMICAL NAME           : D-Glucitol, 1-deoxy-1-(methylamino)-,
                          trioxoantimonate(1-)
CAS REGISTRY NUMBER     : 133-51-7
LAST UPDATED            : 199606
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C7-H17-N-O5.H-O3-Sb
MOLECULAR WEIGHT        : 366.01
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * Glucantime
   * Glucitol, 1-deoxy-1-(methylamino)-, compd. with antimonic acid (1:1), D-
   * D-Glucitol, 1-deoxy-1-(methylamino)-, compd. with antimonic acid (1:1)
   * Meglumine antimonate
   * Methylglucamine antimonate
   * N-Methylglucamine antimonate
   * Protostib
   * 2168-RP
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 700 mg/kg/7D
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - interstitial nephritis
   Kidney, Ureter, Bladder - urine volume increased
   Kidney, Ureter, Bladder - urine volume decreased
REFERENCE :
   MAMEA2 Maroc Medical.  (Casablanca, Morocco)  V.1-55, 1921-75. Discontinued.
    Volume(issue)/page/year: 41,1180,1962
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 27056 mg/kg/30D-I
TOXIC EFFECTS :
   Blood - changes in leukocyte (WBC) count
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - transaminases
REFERENCE :
   HETOEA Human & Experimental Toxicology.  (Macmillan Press Ltd., Brunel Road,
   Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990-
   Volume(issue)/page/year: 11,283,1992
 
                            *** END OF RECORD ***