*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : LZ4366500
CHEMICAL NAME           : D-Glucitol, 1-deoxy-1-(methylamino)-,
                          (R-(R*,R*))-4-((2-((3-(1H-indol-3-yl)-2-methyl-1-oxo-
                          2-(((tricyclo(3.3.1.1(3,7))dec-2-yloxy)carbonyl)amino
                          )propyl)amino)-1-phen ylethyl)amino)- 4-oxobutanoate
                          (salt)
CAS REGISTRY NUMBER     : 130404-91-0
LAST UPDATED            : 199804
DATA ITEMS CITED        : 1
MOLECULAR FORMULA       : C35-H42-N4-O6.C7-H17-N-O5
MOLECULAR WEIGHT        : 810.06
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * CI988
   * PD 134308
 
                       *** HEALTH HAZARD DATA ***
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 2800 mg/kg/2W-I
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - hypermotility, diarrhea
   Nutritional and Gross Metabolic - dehydration
REFERENCE :
   TOPADD Toxicologic Pathology.  (c/o Dr. F.A. de la Iglesia, Warner-Lambert
   Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 
     1978-  Volume(issue)/page/year: 25,441,1997
 
                            *** END OF RECORD ***