*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : LZ4300000
CHEMICAL NAME           : D-Glucitol, 1-deoxy-1-(methylamino)-,
                          3,5-bis(acetylamino)-2,4,6-triiodobenzoate (salt)
                          mixed with 3,5-bis(acetylamino)-2,4,6-triiodobenzoic
                          acid monosodium salt
CAS REGISTRY NUMBER     : 8064-12-8
OTHER CAS REGISTRY NOS. : 19121-26-7
                          39468-26-3
                          51745-36-9
                          63705-10-2
                          78171-11-6
LAST UPDATED            : 199512
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C11-H9-I3-N2-O4.C11-H8-I3-N2-O4.C7-H17-N-O5.Na
MOLECULAR WEIGHT        : 1445.07
WISWESSER LINE NOTATION : 1VMR BI DI FI CVQ EMV1 &1VMR BI DI FI CVO EMV1
                          &Q1YQYQYQYQ1M1 &-NA-
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Angiovist 292
   * Angiovist 370
   * Diatrizoate de sodium et de methylglucamine
   * Hypaque 76
   * Hypaque 85
   * Hypaque-M
   * Hypaque 75M
   * MD 76
   * Meglumine sodium amidotrizoate
   * Penografin-76
   * Radioselectan 76
   * Radioselectan forte
   * Renografin 60
   * Renografin 76
   * Renovist II
   * Sodium meglumine diatrizoate
   * Sodium methylglucamine diatrizoate
   * Triombrast
   * Triyosom C
   * Urografin
   * Urografin 60
   * Urografin 76
   * Urombrine 420
   * Uropolinum
   * Urovison
   * Verografin
   * Verographin
   * Visotrast
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 29200 ug/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - chronic pulmonary edema
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 12(Suppl 1),11,1984
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 19 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YAKUD5 Gekkan Yakuji.  Pharmaceuticals Monthly.  (Yakugyo Jihosha, Inaoka
   Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan)  V.1-   1959-
   Volume(issue)/page/year: 26,921,1984
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 11500 mg/kg
TOXIC EFFECTS :
   Brain and Coverings - recordings from specific areas of CNS
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 26,595,1971
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 22525 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FMTYA2 Farmatsiya (Sofia).  (Hemus, Blvd. Russki 6, Sofia, Bulgaria)  V.1-
   1951-  Volume(issue)/page/year: 32(3),18,1983
 
                            *** END OF RECORD ***