*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : LY5200000
CHEMICAL NAME           : Germanium, metal powder
CAS REGISTRY NUMBER     : 7440-56-4
LAST UPDATED            : 199701
DATA ITEMS CITED        : 9
MOLECULAR FORMULA       : Ge
MOLECULAR WEIGHT        : 72.59
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * Germanium element
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 58 mg/kg/26W-I
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
REFERENCE :
   JJMDAT Japanese Journal of Medicine.  (Nankodo Co., Ltd., POB 5272, Tokyo
   International 100-31, Japan)  V.1-30, 1962-1991.  For publisher information,
   see IEDIEP.  Volume(issue)/page/year: 30,67,1991
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 2 gm/kg/78W-I
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
   Kidney, Ureter, Bladder - changes in both tubules and glomeruli
REFERENCE :
   JJMDAT Japanese Journal of Medicine.  (Nankodo Co., Ltd., POB 5272, Tokyo
   International 100-31, Japan)  V.1-30, 1962-1991.  For publisher information,
   see IEDIEP.  Volume(issue)/page/year: 30,67,1991
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 786 mg/kg/2Y-I
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
   Blood - oxidant related (GPD deficient) anemia
REFERENCE :
   JJMDAT Japanese Journal of Medicine.  (Nankodo Co., Ltd., POB 5272, Tokyo
   International 100-31, Japan)  V.1-30, 1962-1991.  For publisher information,
   see IEDIEP.  Volume(issue)/page/year: 30,67,1991
 
TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3860 mg/m3/4H
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.20-    1982- Volume(issue)/page/year:
   28,571,1990
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 250 mg/m3/6H/4W-I
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - changes in lung weight
   Kidney, Ureter, Bladder - urine volume increased
   Blood - other changes
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.20-    1982- Volume(issue)/page/year:
   28,571,1990

                    *** OCCUPATIONAL EXPOSURE LIMITS ***
 
   OEL-RUSSIA:STEL 2 mg/m3 JAN 1993

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 34770
       No. of Facilities: 56 (estimated)
       No. of Industries: 2
       No. of Occupations: 3
       No. of Employees: 307 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 34770
       No. of Facilities: 16 (estimated)
       No. of Industries: 2
       No. of Occupations: 7
       No. of Employees: 1914 (estimated)
       No. of Female Employees: 279 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***