*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : LX9150000
CHEMICAL NAME           : Gelsemine, monohydrochloride
CAS REGISTRY NUMBER     : 35306-33-3
LAST UPDATED            : 199203
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C20-H22-N2-O2.Cl-H
MOLECULAR WEIGHT        : 358.90
SYNONYMS/TRADE NAMES :
   * Gesemine hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - other changes
   Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
   DUSA** "Dispensatory of the United States of America," 24th ed., Osol, A.
   and G.E. Farrar, Philadelphia, J.B. Lippincott Co., 1947
   Volume(issue)/page/year: 24,497,1947
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 500 ug/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - other changes
   Liver - other changes
   Kidney, Ureter, Bladder - other changes
REFERENCE :
   ZEBLA3 Zeitschrift fuer Biologie.  (Munich, Fed. Rep. Ger.)  V.1-116,
   1865-1971.  Discontinued.  Volume(issue)/page/year: 99,446,1939
 
                            *** END OF RECORD ***