*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : LW5954000
CHEMICAL NAME           : Galanthamine, hydrobromide, mixt. with 4-pyridinamine
                          monohydrochloride
CAS REGISTRY NUMBER     : 53321-09-8
LAST UPDATED            : 199512
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C17-H21-N-O3.C5-H6-N2.Br-H.Cl-H
MOLECULAR WEIGHT        : 498.90
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Nivaline P
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 33 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AMKUDT Acta Medica Kinki University.  (Kinki Univ. Medical Assoc., 380
   Nishiyama, Sayama-cho, Minami-kawachi-gun, Osaka-fu, Japan)   V.1-    1976-
   Volume(issue)/page/year: 19,119,1994
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 14 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - chromodacryorrhea
   Behavioral - muscle contraction or spasticity
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   EKMMA8 Eksperimentalna Meditsina i Morfologiya.  (Hemus, Blvd. Russki 6,
   Sofia, Bulgaria) V.1-    1962-  Volume(issue)/page/year: 25(3),28,1986
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 15600 ug/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - chromodacryorrhea
   Behavioral - muscle contraction or spasticity
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   EKMMA8 Eksperimentalna Meditsina i Morfologiya.  (Hemus, Blvd. Russki 6,
   Sofia, Bulgaria) V.1-    1962-  Volume(issue)/page/year: 25(3),28,1986
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 22 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - chromodacryorrhea
   Behavioral - muscle contraction or spasticity
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   EKMMA8 Eksperimentalna Meditsina i Morfologiya.  (Hemus, Blvd. Russki 6,
   Sofia, Bulgaria) V.1-    1962-  Volume(issue)/page/year: 25(3),28,1986
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 9300 ug/kg
TOXIC EFFECTS :
   Behavioral - excitement
   Gastrointestinal - changes in structure or function of salivary glands
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   EKMMA8 Eksperimentalna Meditsina i Morfologiya.  (Hemus, Blvd. Russki 6,
   Sofia, Bulgaria) V.1-    1962-  Volume(issue)/page/year: 25(3),28,1986
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 22 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   EKMMA8 Eksperimentalna Meditsina i Morfologiya.  (Hemus, Blvd. Russki 6,
   Sofia, Bulgaria) V.1-    1962-  Volume(issue)/page/year: 25(3),28,1986
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 6500 ug/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   EKMMA8 Eksperimentalna Meditsina i Morfologiya.  (Hemus, Blvd. Russki 6,
   Sofia, Bulgaria) V.1-    1962-  Volume(issue)/page/year: 25(3),28,1986
 
                            *** END OF RECORD ***