*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : LW1001000
CHEMICAL NAME           : Gadolinate(2-),
                          (N,N-bis(2-(bis(carboxymethyl)amino)ethyl)glycinato(5
                          -))-, dihydrogen, compd. with
                          1-deoxy-1-(methylamino)-D-glucitol (1:2)
CAS REGISTRY NUMBER     : 86050-77-3
LAST UPDATED            : 199412
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C14-H18-Gd-N3-O10.2C7-H17-N-O5.2H
MOLECULAR WEIGHT        : 858.12
SYNONYMS/TRADE NAMES :
   * Diethylenetriaminepentaacetic acid dimeglumine salt gadolinium chelate
   * Dimeglumine-gadolinium-dtpa
   * Magnevist
   * Resovist
   * SHL 451A
   * ZK 93035
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 9411 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AAJRDX AJR, American Journal of Roentgenology.  (Williams & Wilkins Co., 428
   E. Preston St., Baltimore, MD 21202)  V.126-    1976-
   Volume(issue)/page/year: 142,619,1984
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 612 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AAJRDX AJR, American Journal of Roentgenology.  (Williams & Wilkins Co., 428
   E. Preston St., Baltimore, MD 21202)  V.126-    1976-
   Volume(issue)/page/year: 142,619,1984
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4291 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   TOLED5 Toxicology Letters.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1977-  Volume(issue)/page/year:
   (Suppl),254,1992
 
                            *** END OF RECORD ***