*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : LV1300000
CHEMICAL NAME : 7H-Furo(3,2-g)(1)benzopyran-7-one, 4-methoxy-
CAS REGISTRY NUMBER : 484-20-8
BEILSTEIN REFERENCE NO. : 0019560
REFERENCE : 5-19-06-00004 (Beilstein Handbook Reference)
LAST UPDATED : 199612
DATA ITEMS CITED : 12
MOLECULAR FORMULA : C12-H8-O4
MOLECULAR WEIGHT : 216.20
WISWESSER LINE NOTATION : T C566 DO LVOJ HO1
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
Reproductive Effector
Natural Product
SYNONYMS/TRADE NAMES :
* Bergaptan
* Bergapten
* Bergaptene
* Heraclin
* 6-Hydroxy-4-methoxy-5-benzofuranacrylic acid, gamma-lactone
* Majudin
* 5-Methoxy-6,7-furanocoumarin
* 4-Methoxy-7H-furo(3,2-g)(1)benzopyran-7-one
* 5-Methoxypsoralen
* 5-Mop
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >30 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
48PRAW "Psoralens in Cosmetics and Dermatology, Proceedings of the
International Symposium, Paris, 1981," Cahn, J., et al., eds., Paris,
Pergamon Press France, 1981 Volume(issue)/page/year: -,303,1981
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 8100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
48PRAW "Psoralens in Cosmetics and Dermatology, Proceedings of the
International Symposium, Paris, 1981," Cahn, J., et al., eds., Paris,
Pergamon Press France, 1981 Volume(issue)/page/year: -,303,1981
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 9 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
48PRAW "Psoralens in Cosmetics and Dermatology, Proceedings of the
International Symposium, Paris, 1981," Cahn, J., et al., eds., Paris,
Pergamon Press France, 1981 Volume(issue)/page/year: -,303,1981
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 204 gm/kg/52W-I
TOXIC EFFECTS :
Behavioral - fluid intake
Endocrine - evidence of thyroid hyperfunction
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
48PRAW "Psoralens in Cosmetics and Dermatology, Proceedings of the
International Symposium, Paris, 1981," Cahn, J., et al., eds., Paris,
Pergamon Press France, 1981 Volume(issue)/page/year: -,303,1981
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 800 mg/kg/8D-I
TOXIC EFFECTS :
Behavioral - sleep
Behavioral - food intake (animal)
Skin and Appendages - dermatitis, irritative (after systemic exposure)
REFERENCE :
48PRAW "Psoralens in Cosmetics and Dermatology, Proceedings of the
International Symposium, Paris, 1981," Cahn, J., et al., eds., Paris,
Pergamon Press France, 1981 Volume(issue)/page/year: -,303,1981
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 4368 mg/kg/13W-I
TOXIC EFFECTS :
Liver - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
48PRAW "Psoralens in Cosmetics and Dermatology, Proceedings of the
International Symposium, Paris, 1981," Cahn, J., et al., eds., Paris,
Pergamon Press France, 1981 Volume(issue)/page/year: -,303,1981
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 5600 mg/kg
SEX/DURATION : female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora lutea)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
48PRAW "Psoralens in Cosmetics and Dermatology, Proceedings of the
International Symposium, Paris, 1981," Cahn, J., et al., eds., Paris,
Pergamon Press France, 1981 Volume(issue)/page/year: -,303,1981
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 6720 mg/kg
SEX/DURATION : female 7-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
48PRAW "Psoralens in Cosmetics and Dermatology, Proceedings of the
International Symposium, Paris, 1981," Cahn, J., et al., eds., Paris,
Pergamon Press France, 1981 Volume(issue)/page/year: -,303,1981
** MUTATION DATA **
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 900 mg/kg
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:
25,302,1995
*** REVIEWS ***
IARC Cancer Review:Animal Sufficient Evidence
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,242,1987
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 40,327,1986
IARC Cancer Review:Group 2A
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,242,1987
*** END OF RECORD ***