*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : LV0940000
CHEMICAL NAME : 2H-Furo(2,3-h)(1)benzopyran-2-one
CAS REGISTRY NUMBER : 523-50-2
BEILSTEIN REFERENCE NO. : 0153970
REFERENCE : 5-19-04-00447 (Beilstein Handbook Reference)
LAST UPDATED : 199706
DATA ITEMS CITED : 10
MOLECULAR FORMULA : C11-H6-O3
MOLECULAR WEIGHT : 186.17
WISWESSER LINE NOTATION : T B566 EO LVOJ
COMPOUND DESCRIPTOR : Tumorigen
Drug
Mutagen
SYNONYMS/TRADE NAMES :
* Angecin
* Angelicin (coumarin deriv)
* Furo(2,3-h)coumarin
* Furo(5',4',7,8)coumarin
* 4-Hydroxy-5-benzofuranacrylic acid gamma-lactone
* 3-(4-Hydroxy-5-benzofuranyl)-2-propenoic acid gamma-lactone
* Isopsoralen
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 322 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - ataxia
Behavioral - analgesia
REFERENCE :
IJMRAQ Indian Journal of Medical Research. (Indian Council of Medical
Research, Ansari Nagar, New Delhi 110 029, India) V.1- 1913-
Volume(issue)/page/year: 63,833,1975
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 165 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - ataxia
Behavioral - analgesia
REFERENCE :
IJMRAQ Indian Journal of Medical Research. (Indian Council of Medical
Research, Ansari Nagar, New Delhi 110 029, India) V.1- 1913-
Volume(issue)/page/year: 63,833,1975
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 254 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - ataxia
Behavioral - analgesia
REFERENCE :
IJMRAQ Indian Journal of Medical Research. (Indian Council of Medical
Research, Ansari Nagar, New Delhi 110 029, India) V.1- 1913-
Volume(issue)/page/year: 63,833,1975
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 40 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 58,23,1978
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 50 umol/L
REFERENCE :
BUCABS Bulletin du Cancer. (SPPIF, B.P.22, F-41353 Vineuil, France) V.53-
1966- Volume(issue)/page/year: 67,245,1980
TYPE OF TEST : Gene conversion and mitotic recombination
TEST SYSTEM : Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 100 umol/L
REFERENCE :
BUCABS Bulletin du Cancer. (SPPIF, B.P.22, F-41353 Vineuil, France) V.53-
1966- Volume(issue)/page/year: 67,245,1980
*** REVIEWS ***
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 40,291,1986
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 40,291,1986
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: In vitro mammalian nonhuman micronucleus
EPA GENETOX PROGRAM 1988, Inconclusive: S cerevisiae-reversion
*** END OF RECORD ***