*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : LQ0800000
CHEMICAL NAME           : Formamide,
                          N-((4-amino-2-methyl-5-pyrimidinyl)methyl)-N-(4-hydro
                          xy-1-methyl-2-
                          ((tetrahydrofurfuryl)dithio)-1-butenyl)-,
                          hydrochloride
CAS REGISTRY NUMBER     : 10238-39-8
LAST UPDATED            : 198910
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C17-H26-N4-O3-S2.Cl-H
MOLECULAR WEIGHT        : 435.05
WISWESSER LINE NOTATION : T6N CNJ B1 DZ E1NVHY1&UY2QSS1- BT5OTJ &GH
COMPOUND DESCRIPTOR     : Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Thiamine tetrahydrofurfuryl disulfide hydrochloride
   * TTFD hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 7560 mg/kg
SEX/DURATION            : male 63 day(s) pre-mating
                          female 63 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   TAKHAA Takeda Kenkyusho Ho.  Journal of the Takeda Research Laboratories.
   (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532,
   Japan)  V.29-    1970-  Volume(issue)/page/year: 31,365,1972
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 50400 mg/kg
SEX/DURATION            : male 63 day(s) pre-mating
                          female 63 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   TAKHAA Takeda Kenkyusho Ho.  Journal of the Takeda Research Laboratories.
   (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532,
   Japan)  V.29-    1970-  Volume(issue)/page/year: 31,365,1972
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 2700 mg/kg
SEX/DURATION            : female 8-16 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   JJPAAZ Japanese Journal of Pharmacology.  (Japanese Pharmacological Soc.,
   c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto
   606, Japan)  V.1-    1951-  Volume(issue)/page/year: 22,115,1972
 
                            *** END OF RECORD ***