*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : LL8990000
CHEMICAL NAME           : 9H-Fluoren-9-one, 2,7-bis(2-(diethylamino)ethoxy)-
CAS REGISTRY NUMBER     : 27591-97-5
BEILSTEIN REFERENCE NO. : 2011558
LAST UPDATED            : 199612
DATA ITEMS CITED        : 8
MOLECULAR FORMULA       : C25-H34-N2-O3
MOLECULAR WEIGHT        : 410.61
WISWESSER LINE NOTATION : L B656 HVJ EO2N2&2 KO2N2&2
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Bis-deae-fluorenone
   * 2,7-Bis(2-(diethylamino)ethoxy)-9H-fluoren-9-one
   * Tilorone
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1780 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  No.1-
   1967-  Volume(issue)/page/year: 23,497,1989
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 121 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   23,102,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Immunological Including Allergic - increased immune response
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  No.1-
   1967-  Volume(issue)/page/year: 12,1460,1978
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 4 mg/plate
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   37,2209,1977
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 500 mg/L
REFERENCE :
   RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD
   Pub. Ltd., P.O. Box 966, Westbury, NY 11590)  V.1-    1970-
   Volume(issue)/page/year: 16,523,1977
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Mammal - species unspecified Lymphocyte
DOSE/DURATION           : 100 umol/L
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   11,91,1975

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
   
   EPA GENETOX PROGRAM 1988, Negative: Cell transform.-C3H/10T1/2; In vitro
   SCE-nonhuman

 
                            *** END OF RECORD ***