*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : KQ8560000
CHEMICAL NAME           : Ethylamine,
                          2-((o-tert-butyl-alpha-phenylbenzyl)oxy)-N,N-dimethyl
                          -, hydrochloride
CAS REGISTRY NUMBER     : 5697-60-9
LAST UPDATED            : 198212
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C21-H29-N-O.Cl-H
MOLECULAR WEIGHT        : 347.97
WISWESSER LINE NOTATION : 1X1&1&R BYR&O2N1&1 &GH
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * BS 6534
   * 2-((o-tert-Butyl-alpha-phenylbenzyl)oxy)-N,N-dimethyl-ethylamine  
   hydrochloride
   * Ethanamine, 2-((2-(1,1-dimethylethyl)phenyl)phenylmethoxy)-N,N-dimethyl-, 
    hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - local anesthetic
   Autonomic Nervous System - smooth muscle relaxant (mechanism undefined,
   spasmolytic)
   Vascular - regional or general arteriolar constriction
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 138,62,1962
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 115 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - local anesthetic
   Autonomic Nervous System - smooth muscle relaxant (mechanism undefined,
   spasmolytic)
   Vascular - regional or general arteriolar constriction
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 138,62,1962
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 350 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - local anesthetic
   Autonomic Nervous System - smooth muscle relaxant (mechanism undefined,
   spasmolytic)
   Vascular - regional or general arteriolar constriction
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 138,62,1962
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - local anesthetic
   Autonomic Nervous System - smooth muscle relaxant (mechanism undefined,
   spasmolytic)
   Vascular - regional or general arteriolar constriction
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 138,62,1962
 
                            *** END OF RECORD ***