*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : KQ8420000
CHEMICAL NAME           : Ethylamine,
                          2-((p-bromo-alpha-phenylbenzyl)oxy)-N,N-dimethyl-,
                          hydrochloride
CAS REGISTRY NUMBER     : 1808-12-4
LAST UPDATED            : 199504
DATA ITEMS CITED        : 8
MOLECULAR FORMULA       : C17-H20-Br-N-O.Cl-H
MOLECULAR WEIGHT        : 370.75
WISWESSER LINE NOTATION : ER DYR&O2N1&1 &GH
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Ambodryl hydrochloride
   * Bromazin
   * Bromdiphenylhydramine hydrochloride
   * Bromo-benzdryl
   * beta-(p-Bromobenzhydryloxy)ethyldimethylamine hydrochloride
   * 2-(4-Bromobenzohydryloxy)-ethyl-dimethylamine hydrochloride
   * Bromodiphenhydramine hydrochloride
   * 2-(4-Bromodiphenylmethoxy)ethyldimethylamine
   * 4-Bromo-alpha-phenylbenzyl 2-dimethylaminoethyl ether
   * 2-((p-Bromo-alpha-phenylbenzyl)oxy)-N,N-dimethylethylamine hydrochloride
   * Deserol
   * Ethanamine, 2-((4-bromophenyl)phenylmethoxy)-N,N-dimethyl-, hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 602 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CLDND* Compilation of LD50 Values of New Drugs.  (J.R. MacDougal, Dept. of
   National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa,
   Ont., Canada)
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 55 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CLDND* Compilation of LD50 Values of New Drugs.  (J.R. MacDougal, Dept. of
   National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa,
   Ont., Canada)
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 366 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CLDND* Compilation of LD50 Values of New Drugs.  (J.R. MacDougal, Dept. of
   National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa,
   Ont., Canada)
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 105 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 112,318,1954
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 63 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CLDND* Compilation of LD50 Values of New Drugs.  (J.R. MacDougal, Dept. of
   National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa,
   Ont., Canada)
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 21 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CLDND* Compilation of LD50 Values of New Drugs.  (J.R. MacDougal, Dept. of
   National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa,
   Ont., Canada)

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 81737
       No. of Facilities: 805 (estimated)
       No. of Industries: 1
       No. of Occupations: 1
       No. of Employees: 805 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 81737
       No. of Facilities: 3 (estimated)
       No. of Industries: 1
       No. of Occupations: 1
       No. of Employees: 82 (estimated)
       No. of Female Employees: 14 (estimated)

 
                            *** END OF RECORD ***