*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : KN8970000
CHEMICAL NAME : Ether, diphenyl
CAS REGISTRY NUMBER : 101-84-8
BEILSTEIN REFERENCE NO. : 1364620
REFERENCE : 4-06-00-00568 (Beilstein Handbook Reference)
LAST UPDATED : 199712
DATA ITEMS CITED : 33
MOLECULAR FORMULA : C12-H10-O
MOLECULAR WEIGHT : 170.22
WISWESSER LINE NOTATION : ROR
COMPOUND DESCRIPTOR : Primary Irritant
SYNONYMS/TRADE NAMES :
* Benzene, 1,1'-oxybis-
* Benzene, phenoxy-
* Biphenyl oxide
* Chemcryl JK-EB
* Diphenyl ether
* Diphenyl oxide
* Geranium crystals
* Oxybisbenzene
* Oxydiphenyl
* Phenoxybenzene
* Phenyl ether
* Phenyl oxide
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 10 ppm/140H
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
33,78,1975
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 500 mg/24H
REACTION SEVERITY : Mild
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 12,707,1974
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 10 ppm/140H
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
33,78,1975
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2450 mg/kg
TOXIC EFFECTS :
Behavioral - food intake (animal)
Behavioral - muscle weakness
Gastrointestinal - other changes
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: 0TS0518143
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : >7940 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - acute pulmonary edema
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: 0TS0518143
*** REVIEWS ***
ACGIH TLV-STEL 14 mg/m3 (2 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 7 mg/m3 (1 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 1 ppm (7 mg/m3) (vapor)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,205,1971
OSHA PEL (Gen Indu):8H TWA 1 ppm (7 mg/m3), vapor
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 1 ppm (7 mg/m3), vapor
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 1 ppm (7 mg/m3), vapor
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 1 ppm (7 mg/m3), vapor
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 1 ppm (7 mg/m3);STEL 2 ppm (14 mg/m3) JAN 1993
OEL-AUSTRIA:TWA 1 ppm (7 mg/m3) JAN 1993
OEL-BELGIUM:TWA 1 ppm (7 mg/m3);STEL 2 ppm (14 mg/m3) JAN 1993
OEL-DENMARK:TWA 1 ppm (7 mg/m3) JAN 1993
OEL-FINLAND:TWA 1 ppm (7 mg/m3);STEL 3 ppm (21 mg/m3);Skin JAN 1993
OEL-FRANCE:TWA 1 ppm (7 mg/m3) JAN 1993
OEL-GERMANY:TWA 1 ppm (7 mg/m3) JAN 1993
OEL-HUNGARY:TWA 5 mg/m3;STEL 10 mg/m3;Skin JAN 1993
OEL-THE PHILIPPINES:TWA 1 ppm (7 mg/m3) JAN 1993
OEL-RUSSIA:STEL 5 mg/m3 JAN 1993
OEL-SWITZERLAND:TWA 1 ppm (7 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 1 ppm (7 mg/m3) JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO PHENYL ETHER, vapor-air:10H TWA 1 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 57210
No. of Facilities: 561 (estimated)
No. of Industries: 17
No. of Occupations: 33
No. of Employees: 13791 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 57210
No. of Facilities: 7313 (estimated)
No. of Industries: 62
No. of Occupations: 70
No. of Employees: 90789 (estimated)
No. of Female Employees: 33945 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
NIOSH Analytical Method, 1994: Phenyl ether, 1617
*** END OF RECORD ***