*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : KN5250000
CHEMICAL NAME : Ether, tert-butyl methyl
CAS REGISTRY NUMBER : 1634-04-4
BEILSTEIN REFERENCE NO. : 1730942
REFERENCE : 4-01-00-01615 (Beilstein Handbook Reference)
LAST UPDATED : 199712
DATA ITEMS CITED : 22
MOLECULAR FORMULA : C5-H12-O
MOLECULAR WEIGHT : 88.17
COMPOUND DESCRIPTOR : Reproductive Effector
SYNONYMS/TRADE NAMES :
* tert-Butyl methyl ether
* 2-Methoxy-2-methylpropane
* Methyl tert-butyl ether
* Methyl 1,1-dimethylethyl ether
* Propane, 2-methoxy-2-methyl-
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB87-174603
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 23576 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB87-174603
TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >148 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JSGRA2 Journal of Surgical Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.1- 1961- Volume(issue)/page/year: 53,572,1992
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 148 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JSGRA2 Journal of Surgical Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.1- 1961- Volume(issue)/page/year: 53,572,1992
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 5960 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CHHTAT Zhonghua Yixue Zazhi. Chinese Medical Journal. (China International
Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1915-
Suspended 1967-72. Volume(issue)/page/year: 70,172,1990
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 141 gm/m3/15M
TOXIC EFFECTS :
Behavioral - general anesthetic
REFERENCE :
ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept., 2350
Virginia Ave., Hagerstown, MD 21740) V.1- 1940- Volume(issue)/page/year:
11,455,1950
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1700 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CHHTAT Zhonghua Yixue Zazhi. Chinese Medical Journal. (China International
Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1915-
Suspended 1967-72. Volume(issue)/page/year: 70,172,1990
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 20 gm/kg/14D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in bladder weight
Blood - changes in erythrocyte (RBC) count
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert,
Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
Volume(issue)/page/year: 9(5),525,1990
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 27 gm/kg/90D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in bladder weight
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Nutritional and Gross Metabolic - changes in calcium
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert,
Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
Volume(issue)/page/year: 9(5),525,1990
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1516 ppm/6H/10D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
acute tubular necrosis)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
143,301,1997
** REPRODUCTIVE DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE : 8000 ppm/6H
SEX/DURATION : multigeneration
TOXIC EFFECTS :
Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
per # born alive)
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
Volume(issue)/page/year: 17(S1),S13,1997
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE : 4000 ppm/6H
SEX/DURATION : female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
Volume(issue)/page/year: 17(S1),S21,1997
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE : 8000 ppm/6H
SEX/DURATION : female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
Volume(issue)/page/year: 17(S1),S21,1997
*** REVIEWS ***
ACGIH TLV-Animal carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 144 mg/m3 (40 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 100 mg/m3 JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4267
No. of Facilities: 614 (estimated)
No. of Industries: 6
No. of Occupations: 9
No. of Employees: 5996 (estimated)
No. of Female Employees: 1783 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
NIOSH Analytical Method, 1994: Methyl tert-butyl ether, 1615
*** END OF RECORD ***