*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : KM5600000
CHEMICAL NAME           : Ethanone, 1-(4-chlorophenyl)-
CAS REGISTRY NUMBER     : 99-91-2
BEILSTEIN REFERENCE NO. : 0386014
REFERENCE               : 4-07-00-00639 (Beilstein Handbook Reference)
LAST UPDATED            : 199709
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C8-H7-Cl-O
MOLECULAR WEIGHT        : 154.60
WISWESSER LINE NOTATION : GR DV1
COMPOUND DESCRIPTOR     : Human
SYNONYMS/TRADE NAMES :
   * Acetophenone, 4'-chloro-
   * p-Acetylchlorobenzene
   * 4-Acetylchlorobenzene
   * 4'-Chloroacetophenone
   * 1-(4-Chlorophenyl)ethanone
   * p-Chlorophenyl methyl ketone
   * 4-Chlorophenyl methyl ketone
   * Methyl p-chlorophenyl ketone
   * Methyl 4-chlorophenyl ketone
   * USAF DO-1
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Human
DOSE/DURATION           : 1 mg/m3/1M
TOXIC EFFECTS :
   Sense Organs and Special Senses (Olfaction) - effect, not otherwise
   specified
   Sense Organs and Special Senses (Eye) - lacrimation
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
REFERENCE :
   27ZZA9 "Manual of Pharmacology and Its Applications to Therapeutics and
   Toxicology," 8th ed., Sollman, T., Philadelphia, W.B. Saunders Co., 1957
   Volume(issue)/page/year: 8,192,1957
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1207 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
   (usually neuromuscular blockage)
   Behavioral - muscle weakness
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   PHARAT Pharmazie.  (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18,
   Berlin DDR-1020, Ger. Dem. Rep.)  V.1-    1946-  Volume(issue)/page/year:
   31,317,1976
 
TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1752 mg/m3/15M
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JJATDK JAT, Journal of Applied Toxicology.  (John Wiley & Sons Ltd., Baffins
   Lane, Chichester, W. Sussex PO19 1UD, UK)  V.1-    1981-
   Volume(issue)/page/year: 14,411,1994
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD277-689
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 87600 ug/m3/15M/10D-I
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - acute pulmonary edema
   Endocrine - hyperglycemia
   Endocrine - changes in spleen weight
REFERENCE :
   JJATDK JAT, Journal of Applied Toxicology.  (John Wiley & Sons Ltd., Baffins
   Lane, Chichester, W. Sussex PO19 1UD, UK)  V.1-    1981-
   Volume(issue)/page/year: 14,411,1994

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X7067
       No. of Facilities: 7 (estimated)
       No. of Industries: 1
       No. of Occupations: 1
       No. of Employees: 28 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***