*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : KM2675000
CHEMICAL NAME           : Ethanol,
                          2,2',2'',2'''-((4-piperidinopyrimido(5,4-d)pyrimidine
                          -2,6-diyl)dinitrilo)t etra-
CAS REGISTRY NUMBER     : 13665-88-8
BEILSTEIN REFERENCE NO. : 0587985
LAST UPDATED            : 199612
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C19-H31-N7-O4
MOLECULAR WEIGHT        : 421.57
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 2,6-Bis(diethanolamino)-4-piperidinopyrimido(5,4-d)pyrimidine
   * Compound RA-233
   * Mopidamol
   *   2,2',2'',2'''-((4-Piperidinopyrimido(5,4-d)pyrimidine-2,6-diyl)dinitrilo
     )tetraethanol
   * RA 233
   * Rapentol
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MDACAP Medicamentos de Actualidad.  (J.R. Prous, S.A., Apartado de Correos
   540, 08080 Barcelona, Spain)  V.1-    1965-  Volume(issue)/page/year:
   17,89,1981
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 408 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MDACAP Medicamentos de Actualidad.  (J.R. Prous, S.A., Apartado de Correos
   540, 08080 Barcelona, Spain)  V.1-    1965-  Volume(issue)/page/year:
   17,89,1981
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 465 mg/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   GWXXBX German Offenlegungsschrift Patent Document.  (U.S. Patent and
   Trademark Office, Foreign Patents, Washington, DC 20231)
   Volume(issue)/page/year: #2931573
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 148 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MDACAP Medicamentos de Actualidad.  (J.R. Prous, S.A., Apartado de Correos
   540, 08080 Barcelona, Spain)  V.1-    1965-  Volume(issue)/page/year:
   17,89,1981
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 3 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MDACAP Medicamentos de Actualidad.  (J.R. Prous, S.A., Apartado de Correos
   540, 08080 Barcelona, Spain)  V.1-    1965-  Volume(issue)/page/year:
   17,89,1981
 
                            *** END OF RECORD ***