*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : KL5950000
CHEMICAL NAME : Ethanol, 2-methoxy-, acetate
CAS REGISTRY NUMBER : 110-49-6
BEILSTEIN REFERENCE NO. : 1700761
REFERENCE : 4-02-00-00214 (Beilstein Handbook Reference)
LAST UPDATED : 199712
DATA ITEMS CITED : 49
MOLECULAR FORMULA : C5-H10-O3
MOLECULAR WEIGHT : 118.15
WISWESSER LINE NOTATION : 1VO2O1
COMPOUND DESCRIPTOR : Mutagen
Reproductive Effector
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* Acetate de l'ether monomethylique de l'ethylene-glycol
* Acetate de methyle glycol
* Acetato di metil cellosolve
* Acetic acid 2-methoxyethyl ester
* Aethylenglykolmethylaetheracetat
* Ethylene glycol methyl acetate
* Ethylene glycol methyl ether acetate
* Glycol ether EM acetate
* Glycol monomethyl ether acetate
* MeCsac
* 2-Methoxyaethylacetat
* 2-Methoxyethanol, acetate
* 2-Methoxy-ethyl acetaat
* 2-Methoxyethyl acetate
* 2-Methoxyethyle, acetate de
* 2-Methoxyethylester kyseliny octove
* Methyl cellosolye acetaat
* Methyl cellosolve acetate
* Methylcelosolvacetat
* Methyl glycol acetate
* Methyl glycol monoacetate
* Methylglykolacetat
* 2-Metossietilacetato
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 218 mg
REACTION SEVERITY : Mild
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 3/20/1973
** ACUTE TOXICITY DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Human
DOSE/DURATION : 1000 mg/m3
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Lungs, Thorax, or Respiration - cough
Lungs, Thorax, or Respiration - other changes
REFERENCE :
AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene. (Berlin, Ger.)
V.1-18, 1930-61. For publisher information, see IAEHDW.
Volume(issue)/page/year: 5,1,1933
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2900 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479,
Russia) History Unknown Volume(issue)/page/year: (1),27,1996
TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 7000 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 30,63,1948
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1200 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
Behavioral - muscle weakness
Kidney, Ureter, Bladder - renal function tests depressed
REFERENCE :
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great
Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-
Volume(issue)/page/year: 11,150,1959
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 3100 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479,
Russia) History Unknown Volume(issue)/page/year: (1),27,1996
TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 6 gm/m3/7H
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Behavioral - food intake (animal)
Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene. (Berlin, Ger.)
V.1-18, 1930-61. For publisher information, see IAEHDW.
Volume(issue)/page/year: 5,1,1933
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 3 gm/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene. (Berlin, Ger.)
V.1-18, 1930-61. For publisher information, see IAEHDW.
Volume(issue)/page/year: 5,1,1933
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 5250 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 3/20/1973
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 1250 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
Gastrointestinal - other changes
Kidney, Ureter, Bladder - other changes
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 23,259,1941
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 5 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene. (Berlin, Ger.)
V.1-18, 1930-61. For publisher information, see IAEHDW.
Volume(issue)/page/year: 5,1,1933
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 12500 mg/kg
SEX/DURATION : male 25 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo
Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160,
Japan) V.1- 1959- Volume(issue)/page/year: 21,29,1979
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 50 gm/kg
SEX/DURATION : male 25 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
accessory glands
REFERENCE :
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo
Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160,
Japan) V.1- 1959- Volume(issue)/page/year: 21,29,1979
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 9800 mg/kg
SEX/DURATION : female 7-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB86-197605
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 9800 mg/kg
SEX/DURATION : female 6-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
before birth)
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc.,
41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year:
7,29,1987
** MUTATION DATA **
TYPE OF TEST : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 32000 ppm
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 259,147,1991
TYPE OF TEST : Sex chromosome loss and nondisjunction
TEST SYSTEM : Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 56600 ppm
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 149,339,1985
*** REVIEWS ***
ACGIH TLV-TWA 24 mg/m3 (5 ppm) (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 25 ppm (120 mg/m3) (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,159,1971
OSHA PEL (Gen Indu):8H TWA 25 ppm (120 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 25 ppm (120 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 25 ppm (120 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 25 ppm (120 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 5 ppm (24 mg/m3);Skin JAN 1993
OEL-BELGIUM:TWA 5 ppm (24 mg/m3);Skin JAN 1993
OEL-DENMARK:TWA 5 ppm (24 mg/m3);Skin JAN 1993
OEL-FINLAND:TWA 25 ppm (120 mg/m3);STEL 40 ppm (180 mg/m3);Skin JAN 1993
OEL-FRANCE:TWA 5 ppm (24 mg/m3) JAN 1993
OEL-GERMANY:TWA 5 ppm (25 mg/m3);Skin JAN 1993
OEL-HUNGARY:TWA 25 mg/m3;STEL 50 mg/m3;Skin JAN 1993
OEL-JAPAN:TWA 5 ppm (24 mg/m3);Skin JAN 1993
OEL-THE NETHERLANDS:TWA 5 ppm (24 mg/m3);Skin JAN 1993
OEL-THE PHILIPPINES:TWA 25 ppm (120 mg/m3);Skin JAN 1993
OEL-POLAND:TWA 100 mg/m3 JAN 1993
OEL-RUSSIA:TWA 5 ppm JAN 1993
OEL-SWEDEN:TWA 5 ppm (25 mg/m3);STEL 10 ppm (50 mg/m3);Skin JAN 1993
OEL-SWITZERLAND:TWA 5 ppm (25 mg/m3);STEL 10 ppm (50 mg/m3);Skin JAN 1993
OEL-TURKEY:TWA 25 ppm (120 mg/m3);Skin JAN 1993
OEL-UNITED KINGDOM:TWA 5 ppm (24 mg/m3);Skin JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO EGMEA-air:10H TWA 0.1 ppm (Sk)
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 46935
No. of Facilities: 2907 (estimated)
No. of Industries: 45
No. of Occupations: 49
No. of Employees: 20492 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 46935
No. of Facilities: 658 (estimated)
No. of Industries: 20
No. of Occupations: 27
No. of Employees: 9892 (estimated)
No. of Female Employees: 2801 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
NIOSH Analytical Method, 1994: Methyl cellosolve acetate, 1451
OSHA ANALYTICAL METHOD #53
*** END OF RECORD ***