*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : KK3325000
CHEMICAL NAME           : Ethanol,
                          2-((4-((7-chloro-4-quinolyl)amino)pentyl)ethylamino)-
CAS REGISTRY NUMBER     : 118-42-3
BEILSTEIN REFERENCE NO. : 0253894
REFERENCE               : 5-22-10-00280 (Beilstein Handbook Reference)
LAST UPDATED            : 199703
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C18-H26-Cl-N3-O
MOLECULAR WEIGHT        : 335.92
WISWESSER LINE NOTATION : T66 BNJ EMY1&3N2&2Q IG
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   *   7-Chloro-4-(4-(N-ethyl-N-beta-hydroxyethylamino)-1-methylbutylamino)quin
     oline
   * 7-Chloro-4-(4-(ethyl(2-hydroxyethyl)amino)-1-methylbutylamino)quinoline
   * 7-Chloro-4-(5-(N-ethyl-N-2-hydroxyethylamino)-2-pentyl)aminoquinoline
   * 2-((4-((7-Chloro-4-quinolyl)amino)pentyl)ethylamino)ethanol
   * Hydroxychloroquine
   * Plaquenil
   * WIN 1258
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 600 mg/kg
TOXIC EFFECTS :
   Brain and Coverings - increased intracranial pressure
   Behavioral - convulsions or effect on seizure threshold
   Cardiac - other changes
REFERENCE :
   JATOD3 Journal of Analytical Toxicology.  (Preston Pub. Inc., POB 48312,
   Niles, IL 60648) V.1-    1977-  Volume(issue)/page/year: 14,186,1990
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 88 mg/kg/11D-I
TOXIC EFFECTS :
   Skin and Appendages - dermatitis, allergic (after systemic exposure)
REFERENCE :
   JAADDB Journal of the American Academy of Dermatology.  (C.V. Mosby Co.,
   11830 Westline Industrial Dr., St. Louis, MO 63141)  1979-
   Volume(issue)/page/year: 12,857,1985
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 112 mg/kg/2W-I
TOXIC EFFECTS :
   Skin and Appendages - dermatitis, irritative (after systemic exposure)
REFERENCE :
   JRHUA9 Journal of Rheumatology.  (920 Yonge St., Suite 608, Toronto, Ont.,
   Canada)  V.1-    1974-  Volume(issue)/page/year: 12,391,1985
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 429 mg/kg/25D
TOXIC EFFECTS :
   Blood - agranulocytosis
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 1,1275,1965
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 154 mg/kg/18D-I
TOXIC EFFECTS :
   Behavioral - toxic psychosis
REFERENCE :
   JAADDB Journal of the American Academy of Dermatology.  (C.V. Mosby Co.,
   11830 Westline Industrial Dr., St. Louis, MO 63141)  1979-
   Volume(issue)/page/year: 12,863,1985
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1240 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 12,184,1969
 
                            *** END OF RECORD ***