*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : KI7951500
CHEMICAL NAME           : Ethanesulfonic acid, 2-hydroxy-, compd. with
                          5-methyl-6-(((3,4,5-trimethoxyphenyl)amino)
                          methyl)-2,4-quinazolinediamine
CAS REGISTRY NUMBER     : 117052-25-2
LAST UPDATED            : 199503
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C19-H23-N5-O3.(C2-H6-O4-S)x
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Trimetrexate isethionate salt
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 295 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   18,115,1992
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 325 mg/kg/5D-C
TOXIC EFFECTS :
   Behavioral - food intake (animal)
   Blood - changes in leukocyte (WBC) count
   Related to Chronic Data - death
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   18,115,1992
 
                            *** END OF RECORD ***