*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : KI7213500
CHEMICAL NAME           : Ethanesulfonamide,
                          2-((((2-chloroethyl)nitrosoamino)carbonyl)amino)-N,N-
                          dimethyl-
CAS REGISTRY NUMBER     : 85977-49-7
LAST UPDATED            : 199406
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C7-H15-Cl-N4-O4-S
MOLECULAR WEIGHT        : 286.77
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 1-(2-Chloroethyl)-3-(2-(dimethylaminosulfonyl)ethyl)-1-nitrosourea
   *   2-((((2-Chloroethyl)nitrosoamino)carbonyl)amino)-N,N-dimethylethanesulfo
     namide
   * LS-2667
   * Tauromustina
   * Tauromustine
   * TCNU
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 39 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
   Liver - fatty liver degeneration
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   INNDDK Investigational New Drugs. The Journal of New Anticancer Agents.
   Kluwer Academic Pub., POB 358, Accord Stn., Hingham, MA 02018)  V.1- 1983- 
   Volume(issue)/page/year: 6,19,1988
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 32 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
   Liver - fatty liver degeneration
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   INNDDK Investigational New Drugs. The Journal of New Anticancer Agents.
   Kluwer Academic Pub., POB 358, Accord Stn., Hingham, MA 02018)  V.1- 1983- 
   Volume(issue)/page/year: 6,19,1988
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 36 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - other changes
   Liver - fatty liver degeneration
   Blood - thrombocytopenia
REFERENCE :
   INNDDK Investigational New Drugs. The Journal of New Anticancer Agents.
   Kluwer Academic Pub., POB 358, Accord Stn., Hingham, MA 02018)  V.1- 1983- 
   Volume(issue)/page/year: 6,19,1988
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 42 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - other changes
   Liver - fatty liver degeneration
   Blood - thrombocytopenia
REFERENCE :
   INNDDK Investigational New Drugs. The Journal of New Anticancer Agents.
   Kluwer Academic Pub., POB 358, Accord Stn., Hingham, MA 02018)  V.1- 1983- 
   Volume(issue)/page/year: 6,19,1988
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 23833 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year:
   11,585,1986
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >7500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year:
   11,585,1986
 
                            *** END OF RECORD ***