*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : KI1420000
CHEMICAL NAME : Ethane, 1,2-difluoro-1,1,2,2-tetrachloro-
CAS REGISTRY NUMBER : 76-12-0
BEILSTEIN REFERENCE NO. : 1740336
REFERENCE : 4-01-00-00146 (Beilstein Handbook Reference)
LAST UPDATED : 199712
DATA ITEMS CITED : 33
MOLECULAR FORMULA : C2-Cl4-F2
MOLECULAR WEIGHT : 203.82
WISWESSER LINE NOTATION : GXGFXGGF
COMPOUND DESCRIPTOR : Tumorigen
Primary Irritant
SYNONYMS/TRADE NAMES :
* CFC-112
* Daiflon 112
* Daiflon S2
* 1,2-Difluoro-1,1,2,2-tetrachloroethane
* Ethane, 1,1,2,2-tetrachloro-1,2-difluoro-
* F-112
* Freon 112
* Genetron 112
* Halocarbon 112
* R 112
* Refrigerant 112
* 1,1,2,2-Tetrachloro-1,2-difluoroethane
* Ucon 112
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST : Open irritation test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 100%/24H
REACTION SEVERITY : Mild
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year:
27,332,1966
TYPE OF TEST : Rinsed with water
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 100 mg/20S
REACTION SEVERITY : Mild
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year:
27,332,1966
** ACUTE TOXICITY DATA **
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2 pph/15M
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
HUTODJ Human Toxicology. (Macmillan Press Ltd., Houndmills, Basingstoke,
Hants., RG 21 2XS, UK) V.1- 1981- Volume(issue)/page/year: 1,239,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
GKNT, 1982 Volume(issue)/page/year: -,54,1982
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 50 gm/m3/2H
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
TLSMA6 Trudy Leningradskogo Sanitarno-Gigienicheskogo Meditsinskogo
Instituta. (Leningrad, Russia) V.1-145, 1949-82. Discontinued.
Volume(issue)/page/year: 75,241,1963
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : >10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0520705
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1000 ppm/6H/31D-I
TOXIC EFFECTS :
Liver - other changes
Blood - leukopenia
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year:
27,332,1966
*** REVIEWS ***
ACGIH TLV-TWA 4170 mg/m3 (500 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 500 ppm (4170 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,249,1971
OSHA PEL (Gen Indu):8H TWA 500 ppm (4170 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 500 ppm (4170 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 500 ppm (4170 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 500 ppm (4170 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 500 ppm (4170 mg/m3) JAN 1993
OEL-BELGIUM:TWA 500 ppm (4170 mg/m3) JAN 1993
OEL-DENMARK:TWA 500 ppm (4170 mg/m3) JAN 1993
OEL-FINLAND:TWA 500 ppm (4170 mg/m3);STEL 625 ppm (5215 mg/m3) JAN 1993
OEL-FRANCE:TWA 500 ppm (4760 mg/m3) JAN 1993
OEL-GERMANY:TWA 200 ppm (1690 mg/m3) JAN 1993
OEL-THE NETHERLANDS:TWA 500 ppm (4170 mg/m3) JAN 1993
OEL-THE PHILIPPINES:TWA 500 ppm (4170 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 500 ppm (4200 mg/m3);STEL 1000 ppm JAN 1993
OEL-UNITED KINGDOM:TWA 100 ppm (834 mg/m3);STEL 100 ppm JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO 1,1,2,2-TETRACHLORO-1,2-DIFLUOROETHANE-air:TWA 500 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 71447
No. of Facilities: 451 (estimated)
No. of Industries: 8
No. of Occupations: 7
No. of Employees: 7803 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 71447
No. of Facilities: 95 (estimated)
No. of Industries: 5
No. of Occupations: 5
No. of Employees: 1434 (estimated)
No. of Female Employees: 191 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
NIOSH Analytical Method, 1994: 1,1,2,2-Tetrachloro-1,2-difluoroethane, 1016
NTP Toxicity studies, RPT# TOX-45, October 1997
*** END OF RECORD ***