*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : KI1050000
CHEMICAL NAME : Ethane, 1,1-dichloro-1-nitro-
CAS REGISTRY NUMBER : 594-72-9
BEILSTEIN REFERENCE NO. : 1751184
REFERENCE : 4-01-00-00173 (Beilstein Handbook Reference)
LAST UPDATED : 199712
DATA ITEMS CITED : 31
MOLECULAR FORMULA : C2-H3-Cl2-N-O2
MOLECULAR WEIGHT : 143.96
WISWESSER LINE NOTATION : WNXGG1
COMPOUND DESCRIPTOR : Agricultural Chemical
Mutagen
SYNONYMS/TRADE NAMES :
* 1,1-Dichloor-1-nitroethaan
* 1,1-Dichlor-1-nitroaethan
* Dichloronitroethane
* 1,1-Dichloro-1-nitroethane
* 1,1-Dicloro-1-nitroetano
* Ethide
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 410 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BESAAT Bulletin of the Entomological Society of America. (Entomological
Soc. of America, 4603 Calvert Rd., College Park, MD 20740) V.1- 1955-
Volume(issue)/page/year: 12,161,1966
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 240 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KHFZAN Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal.
For English translation, see PCJOAU. (V/O Mezhdunarodnaya Kniga, 113095
Moscow, USSR) V.1- 1967- Volume(issue)/page/year: 10(6),53,1976
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 150 mg/kg
TOXIC EFFECTS :
Vascular - other changes
Lungs, Thorax, or Respiration - acute pulmonary edema
Gastrointestinal - ulceration or bleeding from stomach
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 27,95,1945
TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 580 mg/m3/6H
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - cough
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 27,95,1945
TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 580 mg/m3/6H
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - cough
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 27,95,1945
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 333 ug/plate
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:
19(Suppl 21),2,1992
*** REVIEWS ***
ACGIH TLV-TWA 12 mg/m3 (2 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD:air-CL 10 ppm (60 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,82,1971
OSHA PEL (Gen Indu):CL 10 ppm (60 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):CL 10 ppm (60 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):CL 10 ppm (60 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):CL 10 ppm (60 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 2 ppm (10 mg/m3) JAN 1993
OEL-AUSTRIA:TWA 10 ppm (60 mg/m3) JAN 1993
OEL-BELGIUM:TWA 2 ppm (12 mg/m3) JAN 1993
OEL-DENMARK:STEL 2 ppm (12 mg/m3) JAN 1993
OEL-FINLAND:TWA 10 ppm (60 mg/m3);STEL 20 ppm (120 mg/m3) JAN 1993
OEL-FRANCE:TWA 2 ppm (10 mg/m3) JAN 1993
OEL-GERMANY:TWA 10 ppm (60 mg/m3) JAN 1993
OEL-THE NETHERLANDS:TWA 2 ppm (10 mg/m3) JAN 1993
OEL-THE PHILIPPINES:TWA 10 ppm (60 mg/m3) JAN 1993
OEL-POLAND:TWA 30 mg/m3 JAN 1993
OEL-SWITZERLAND:TWA 2 ppm (12 mg/m3) JAN 1993
OEL-THAILAND:TWA 10 ppm (60 mg/m3) JAN 1993
OEL-TURKEY:TWA 10 ppm (60 mg/m3) JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO 1,1-DICHLORO-1-NITROETHANE-air:10H TWA 2 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
*** STATUS IN U.S. ***
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
NIOSH Analytical Method, 1994: 1,1-Dichloro-1-nitroethane, 1601
*** END OF RECORD ***