*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : KH7705000
CHEMICAL NAME : Ethane, chloroepoxy-
CAS REGISTRY NUMBER : 7763-77-1
BEILSTEIN REFERENCE NO. : 0102403
REFERENCE : 5-17-01-00008 (Beilstein Handbook Reference)
LAST UPDATED : 199710
DATA ITEMS CITED : 16
MOLECULAR FORMULA : C2-H3-Cl-O
MOLECULAR WEIGHT : 78.50
WISWESSER LINE NOTATION : T30TJ BG
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* Chloroethylene oxide
* Chlorooxirane
* Monochloroethylene oxide
* Oxirane, chloro-
*** HEALTH HAZARD DATA ***
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 128 mg/kg/42W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
40,352,1980
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 400 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 32,93,1975
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 500 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 152,147,1985
TYPE OF TEST : DNA damage
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 1 mmol/L
REFERENCE :
IAPUDO IARC Publications. (WHO Publications Centre USA, 49 Sheridan Ave.,
Albany, NY 12210) No.27- 1979- Volume(issue)/page/year: 70,345,1986
TYPE OF TEST : DNA repair
TEST SYSTEM : Bacteria - Bacillus subtilis
DOSE/DURATION : 260 mmol/L
REFERENCE :
37ATAD "Prevention and Detection of Cancer, Proceedings of the 3rd
International Symposium on Detection and Prevention of Cancer," New York,
Marcel Dekker, 1977 Volume(issue)/page/year: -,155,1977
TYPE OF TEST : Gene conversion and mitotic recombination
TEST SYSTEM : Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 1 mmol/L
REFERENCE :
TOERD9 Toxicological European Research. (S.P.E., 10, Ave. de Messine, 75008
Paris, France) V.1- 1978- Volume(issue)/page/year: 3,131,1981
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Yeast - Schizosaccharomyces pombe
DOSE/DURATION : 500 umol/L
REFERENCE :
COINAV Colloques Internationaux du Centre National de la Recherche
Scientifique. (Kluwer Academic Pub., POB 358, Accord Stn., Hingham, MA
02018) V.1- 1946- Volume(issue)/page/year: 256,315,1977
TYPE OF TEST : Gene conversion and mitotic recombination
TEST SYSTEM : Yeast - Schizosaccharomyces pombe
DOSE/DURATION : 40 umol/L
REFERENCE :
COINAV Colloques Internationaux du Centre National de la Recherche
Scientifique. (Kluwer Academic Pub., POB 358, Accord Stn., Hingham, MA
02018) V.1- 1946- Volume(issue)/page/year: 256,315,1977
TYPE OF TEST : DNA inhibition
ROUTE OF EXPOSURE : Intravenous
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 5 gm/kg
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year:
17,239,1977
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 6 umol/L
REFERENCE :
IJCNAW International Journal of Cancer. (International Union Against
Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.1- 1966-
Volume(issue)/page/year: 16,639,1975
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: V79 cell culture-gene mutation
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion; S
pombe-reversion
EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
*** END OF RECORD ***