*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : KH8587087
CHEMICAL NAME           : 1,2-Ethanediamine, N,N'-bis(2-aminoethyl)-,
                          tetrahydrochloride
CAS REGISTRY NUMBER     : 4961-40-4
LAST UPDATED            : 199701
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C6-H18-N4.4Cl-H
MOLECULAR WEIGHT        : 292.12
SYNONYMS/TRADE NAMES :
   * N,N'-Bis(2-aminoethyl)-1,2-ethanediamine tetrahydrochloride
   * Trientine tetrahydrochloride
   * Triethylenetetramine, tetrahydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2285 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - cyanosis
   Lungs, Thorax, or Respiration - other changes
   Gastrointestinal - ulceration or bleeding from stomach
REFERENCE :
   TOLED5 Toxicology Letters.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1977-  Volume(issue)/page/year:
   (Suppl),246,1992
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 657 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD
   Pub. Ltd., P.O. Box 966, Westbury, NY 11590)  V.1-    1970-
   Volume(issue)/page/year: 14,153,1976
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 51390 mg/kg/90D-I
TOXIC EFFECTS :
   Liver - other changes
   Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
   Nutritional and Gross Metabolic - changes in metals, not otherwise specified
REFERENCE :
   TOLED5 Toxicology Letters.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1977-  Volume(issue)/page/year:
   (Suppl),246,1992

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***