*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : KH8587040
CHEMICAL NAME           : 1,2-Ethanediamine,
                          N-benz(c)acridin-7-yl-N'-(2-chloroethyl)-,
                          dihydrochloride, hydrate
CAS REGISTRY NUMBER     : 38915-49-0
LAST UPDATED            : 199410
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C21-H20-Cl-N3.2Cl-H.H2-O
MOLECULAR WEIGHT        : 439.82
WISWESSER LINE NOTATION : T D6 B666 CNJ JM2M2G &GH 2 &QH
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Benz(c)acridine, 7-((2-((2-chloroethyl)amino)ethyl)amino)-,  
   dihydrochloride hydrate
   * 7-((2-((2-Chloroethyl)amino)ethyl)amino)benz(c)acridine dihydrochloride  
   hydrate
   * ICR 312
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD20 - Lethal Dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 176 mg/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 15,739,1972
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 5 ug/plate
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 15,739,1972

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test

 
                            *** END OF RECORD ***