*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : KH8575000
CHEMICAL NAME : 1,2-Ethanediamine
CAS REGISTRY NUMBER : 107-15-3
BEILSTEIN REFERENCE NO. : 0605263
REFERENCE : 4-04-00-01166 (Beilstein Handbook Reference)
LAST UPDATED : 199712
DATA ITEMS CITED : 59
MOLECULAR FORMULA : C2-H8-N2
MOLECULAR WEIGHT : 60.12
WISWESSER LINE NOTATION : Z2Z
COMPOUND DESCRIPTOR : Mutagen
Reproductive Effector
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* Aethaldiamin
* Aethylenediamin
* 1,2-Diaminoaethan
* 1,2-Diamino-ethaan
* 1,2-Diaminoethane
* 1,2-Diamino-ethano
* Dimethylenediamine
* Ethyleendiamine
* Ethylendiamine
* Ethylenediamine
* 1,2-Ethylenediamine
* Ethylenediamine
* Ethylene-diamine
* NCI-C60402
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST : Open irritation test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 450 mg
REACTION SEVERITY : Moderate
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 12/15/1971
TYPE OF TEST : Open irritation test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 10 mg/24H
REACTION SEVERITY : Severe
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 4,119,1951
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 750 ug
REACTION SEVERITY : Severe
REFERENCE :
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N.
Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
Volume(issue)/page/year: 29,1363,1946
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 750 ug/24H
REACTION SEVERITY : Severe
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,440,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Human
DOSE/DURATION : 200 ppm
TOXIC EFFECTS :
Peripheral Nerve and Sensation - paresthesis
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 9,223,1954
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1200 mg/kg
TOXIC EFFECTS :
Behavioral - ataxia
REFERENCE :
MTPEEI Meditsina Truda i Promyshlennaya Ekologiya. Industrial Medicine and
Ecology. (Mezhdunarodnaya Kniga, ul.B. Yakimanka, 39 117049 Moscow, Russia)
No.1- 1993- Volume(issue)/page/year: (1),38,1997
TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 4000 ppm/8H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 4,119,1951
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 76 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
21,454,1972
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
GKNT, 1982 Volume(issue)/page/year: -,66,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1 gm/kg
TOXIC EFFECTS :
Behavioral - ataxia
REFERENCE :
MTPEEI Meditsina Truda i Promyshlennaya Ekologiya. Industrial Medicine and
Ecology. (Mezhdunarodnaya Kniga, ul.B. Yakimanka, 39 117049 Moscow, Russia)
No.1- 1993- Volume(issue)/page/year: (1),38,1997
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 300 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
GKNT, 1982 Volume(issue)/page/year: -,66,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CHTPBA Chimica Therapeutica. (Paris, France) V.1-8, 1965-73. For
publisher information, see EJMCA5. Volume(issue)/page/year: 4,136,1969
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1295,1935
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 730 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 4,119,1951
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1295,1935
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 470 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Gastrointestinal - other changes
Kidney, Ureter, Bladder - other changes
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 23,259,1941
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 3500 mg/kg/7D-C
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0571059
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 39 gm/kg/13W-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Blood - hemorrhage
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0536438
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 700 ug/m3/17W-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Blood - changes in spleen
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
REFERENCE :
VMDKAM Voprosy Meditsinskoi Khimii. Problems of Medical Chemistry. (V/O Me
zhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1955-
Volume(issue)/page/year: 38(2),1932
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 225 ppm/7H/30D-I
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 9,223,1954
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 540 mg/kg/6W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - changes in lung weight
Liver - liver function tests impaired
Kidney, Ureter, Bladder - other changes in urine composition
REFERENCE :
MTPEEI Meditsina Truda i Promyshlennaya Ekologiya. Industrial Medicine and
Ecology. (Mezhdunarodnaya Kniga, ul.B. Yakimanka, 39 117049 Moscow, Russia)
No.1- 1993- Volume(issue)/page/year: (1),38,1997
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 3200 mg/kg
SEX/DURATION : female 6-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc.,
41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year:
7,29,1987
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 33 ug/plate
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 5(Suppl
1),3,1983
*** REVIEWS ***
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 25 mg/m3 (10 ppm) (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
TOXICOLOGY REVIEW
JJOMDZ JOM, Journal of Occupational Medicine. (American Occupational
Medicine Assoc., 150 N. Wacker Dr., Chicago, IL 60606) V.10- 1968-
Volume(issue)/page/year: 15,808,1973
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year:
54,7740,1989
MSHA STANDARD-air:TWA 10 ppm (25 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,109,1971
OSHA PEL (Gen Indu):8H TWA 10 ppm (25 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 10 ppm (25 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 10 ppm (25 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 10 ppm (25 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 10 ppm (25 mg/m3) JAN 1993
OEL-BELGIUM:TWA 10 ppm (25 mg/m3) JAN 1993
OEL-DENMARK:TWA 10 ppm (25 mg/m3) JAN 1993
OEL-FINLAND:TWA 10 ppm (25 mg/m3);STEL 20 ppm (50 mg/m3) JAN 1993
OEL-FRANCE:TWA 10 ppm (25 mg/m3);STEL 15 ppm (35 mg/m3) JAN 1993
OEL-GERMANY:TWA 10 ppm (25 mg/m3) JAN 1993
OEL-JAPAN:TWA 10 ppm (25 mg/m3) JAN 1993
OEL-THE NETHERLANDS:TWA 10 ppm (25 mg/m3) JAN 1993
OEL-THE PHILIPPINES:TWA 10 ppm (25 mg/m3) JAN 1993
OEL-POLAND:TWA 2 mg/m3 JAN 1993
OEL-RUSSIA:TWA 10 ppm;STEL 2 mg/m3 JAN 1993
OEL-SWEDEN:TWA 10 ppm (25 mg/m3);STEL 15 ppm (35 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 10 ppm (25 mg/m3);STEL 20 ppm (50 mg/m3) JAN 1993
OEL-TURKEY:TWA 10 ppm (25 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 10 ppm (25 mg/m3) JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO ETHYLENEDIAMINE-air:10H TWA 10 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 32220
No. of Facilities: 2126 (estimated)
No. of Industries: 33
No. of Occupations: 35
No. of Employees: 15918 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 32220
No. of Facilities: 6260 (estimated)
No. of Industries: 77
No. of Occupations: 85
No. of Employees: 113007 (estimated)
No. of Female Employees: 29888 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: CHO gene mutation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
NIOSH Analytical Method, 1994: Ethylenediamine, 2540
OSHA ANALYTICAL METHOD #ID-60
*** END OF RECORD ***