*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : KD1920700
CHEMICAL NAME           : 2,7-(Epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b)
                          furan-1,11(2H)-dione, 5,6,9,17,19,21-
                          hexahydroxy-2,4,12,16,18,20,22-heptamethyl-23-methoxy
                          -8-(morpholinomethyl) -, 21-acetate
CAS REGISTRY NUMBER     : 4075-43-8
LAST UPDATED            : 199712
DATA ITEMS CITED        : 1
MOLECULAR FORMULA       : C42-H56-N2-O13
MOLECULAR WEIGHT        : 797.00
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * NCI 144-143
   * PF-49
   * Rifamycin, 8-(morpholinomethyl)-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 188 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   38KLAC "Structure-Activity Relationship among the Semisynthetic
   Antibiotics,"  Perlman, D., ed., New York, Academic Press, 1977
   Volume(issue)/page/year: -,531,1977
 
                            *** END OF RECORD ***