*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : KH2890000
CHEMICAL NAME           : Ethanaminium,
                          2-(((hexadecyloxy)hydroxyphosphinyl)oxy)-N,N,N-trimet
                          hyl-, hydroxide, inner salt
CAS REGISTRY NUMBER     : 58066-85-6
BEILSTEIN REFERENCE NO. : 3690495
REFERENCE               : 4-04-00-01460 (Beilstein Handbook Reference)
LAST UPDATED            : 199712
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C21-H46-N-O4-P
MOLECULAR WEIGHT        : 407.65
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Choline phosphate, hexadecyl ester, hydroxide, inner salt
   * D 18506
   * 2-(((Hexadecyloxy)hydroxyphosphinyl)oxy)-N,N,N-trimethylethanaminium  
   hydroxide, inner salt
   * Hexadecylphosphocholine
   * Hexadecylphosphorylcholine
   * n-Hexadecylphosphorylcholine
   * MIL
   * Miltefosine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 246 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - changes in structure or function of salivary glands
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   LPDSAP Lipids.  (American Oil Chemists' Soc., POB 5037, Stn. A., Champaign,
   IL 61820)  V.1-    1966-  Volume(issue)/page/year: 22,930,1987
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 560 mg/kg/4W-I
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
   Related to Chronic Data - death
REFERENCE :
   LPDSAP Lipids.  (American Oil Chemists' Soc., POB 5037, Stn. A., Champaign,
   IL 61820)  V.1-    1966-  Volume(issue)/page/year: 22,930,1987
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 510 mg/kg/11D-I
TOXIC EFFECTS :
   Gastrointestinal - alteration in gastric secretion
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
   Related to Chronic Data - death
REFERENCE :
   CCPHDZ Cancer Chemotherapy and Pharmacology.  (Springer-Verlag New York,
   Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094)  V.1-    1978-
   Volume(issue)/page/year: 32,437,1993
 
                            *** END OF RECORD ***