*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : KG7980000
CHEMICAL NAME           : Estr-4-en-3-one, 17-beta-hydroxy-7-alpha,17-dimethyl-
CAS REGISTRY NUMBER     : 3704-09-4
BEILSTEIN REFERENCE NO. : 5565683
LAST UPDATED            : 199612
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C20-H30-O2
MOLECULAR WEIGHT        : 302.50
WISWESSER LINE NOTATION : L E5 B666 OVTJ E1 FQ F1 K1
COMPOUND DESCRIPTOR     : Tumorigen
                          Reproductive Effector
                          Hormone
SYNONYMS/TRADE NAMES :
   * Estr-4-en-3-one, 17-hydroxy-7,17-dimethyl-, (7-alpha,17-beta)-
   * 17-beta-Hydroxy-7-alpha,17-dimethylestr-4-en-3-one
   * Miboleron
   * Mibolerone
   * U 10997
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 8985 ug/kg/9.6Y-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Reproductive - Tumorigenic effects - ovarian tumors
REFERENCE :
   TOPADD Toxicologic Pathology.  (c/o Dr. F.A. de la Iglesia, Warner-Lambert
   Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 
     1978-  Volume(issue)/page/year: 13,177,1985
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 800 ug/kg
SEX/DURATION            : female 10 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
   STEDAM Steroids.  (Holden-Day Inc., 4432 Telegraph Ave., Oakland, CA 94609)
   V.1-    1963-  Volume(issue)/page/year: 9,235,1967
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE                    : 196 ug/kg
SEX/DURATION            : female 6-61 day(s) after conception
                          lactating female 42 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
   AJVRAH American Journal of Veterinary Research.  (American Veterinary
   Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196)  V.1-    1940-
   Volume(issue)/page/year: 39,837,1978
 
                            *** END OF RECORD ***