*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : KG7962000
CHEMICAL NAME           : Estr-5(10)-en-3-one,
                          17-alpha-butadiynyl-17-beta-hydroxy-
CAS REGISTRY NUMBER     : 2010-50-6
LAST UPDATED            : 198910
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C22-H26-O2
MOLECULAR WEIGHT        : 322.48
WISWESSER LINE NOTATION : L E5 B666 OV AU- MTJ E1 FQ F1UU2UU1
COMPOUND DESCRIPTOR     : Reproductive Effector
                          Hormone
SYNONYMS/TRADE NAMES :
   * 17-alpha-Butadiynyl-17-beta-hydroxyestr-5(10)-en-3-one
   * 17-alpha-Butadiynyl-17-beta-hydroxy-5(10)-estren-3-one
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 27500 ug/kg
SEX/DURATION            : female 11 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
   STEDAM Steroids.  (Holden-Day Inc., 4432 Telegraph Ave., Oakland, CA 94609)
   V.1-    1963-  Volume(issue)/page/year: 4,801,1964
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 10 mg/kg
SEX/DURATION            : female 2-3 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
REFERENCE :
   STEDAM Steroids.  (Holden-Day Inc., 4432 Telegraph Ave., Oakland, CA 94609)
   V.1-    1963-  Volume(issue)/page/year: 4,801,1964
 
                            *** END OF RECORD ***