*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : KG7220000
CHEMICAL NAME           : Estra-1,3,5(10)-triene-3,17-diol, (17-beta)-,
                          3-benzoate 17-((4-(4-(bis(2-hydroxyethyl)amino)
                          phenyl)-1-oxobutoxy)acetate)
LAST UPDATED            : 199209
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C41-H49-N-O8
MOLECULAR WEIGHT        : 683.91
SYNONYMS/TRADE NAMES :
   * KM 2400
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 20,3441,1986
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1750 mg/kg/5W-C
TOXIC EFFECTS :
   Liver - changes in liver weight
   Endocrine - changes in pituitary weight
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 20,3441,1986
 
                            *** END OF RECORD ***