*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : KG4200000
CHEMICAL NAME           : Estradiol, 3-benzoate mixed with progesterone (1:14
                          moles)
CAS REGISTRY NUMBER     : 8000-03-1
OTHER CAS REGISTRY NOS. : 88161-47-1
LAST UPDATED            : 198910
DATA ITEMS CITED        : 3
COMPOUND DESCRIPTOR     : Tumorigen
                          Reproductive Effector
                          Hormone
SYNONYMS/TRADE NAMES :
   * Estradiol benzoate mixed with progesterone (1:14 moles)
   * Estra-1,3,5(10)-triene-3,17-beta-diol 3-benzoate mixed with progesterone  
   (1:14 moles)
   * Progesterone mixed with estradiol benzoate (14:1 moles)
   * Progesterone mixed with estradiol, 3-benzoate (14:1 moles)
   * Progesterone mixed with estra-1,3,5(10)-triene-3,17-beta-diol 3-benzoate  
   (14:1 moles)
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 338 mg/kg/39W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Reproductive - Tumorigenic effects - uterine tumors
REFERENCE :
   YJBMAU Yale Journal of Biology and Medicine.  (333 Cedar St., New Haven, CT
   06510)  V.1-    1928-  Volume(issue)/page/year: 12,213,1939
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Primate - monkey
DOSE                    : 53 mg/kg
SEX/DURATION            : female 20-21 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 35,119,1987
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Primate - monkey
DOSE                    : 159 mg/kg
SEX/DURATION            : female 20-35 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 35,119,1987
 
                            *** END OF RECORD ***