*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : KE8815000
CHEMICAL NAME           : Ergotoxine, monoethanesulfonate (salt)
CAS REGISTRY NUMBER     : 8047-28-7
LAST UPDATED            : 198910
DATA ITEMS CITED        : 6
COMPOUND DESCRIPTOR     : Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Ecboline ethanesulfonate
   * Ergotoxine ethanesulfonate
   * Erogtoxine ethanesulphonate
   * Ergotoxine ethansulfonate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 40 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Behavioral - tremor
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   HXPHAU Handbuch der Experimentellen Pharmakologie.  (Berlin, Ger.)  New
   series: V.1-49, 1935-78. For publisher information, see HEPHD2.
   Volume(issue)/page/year: 6,103,1938
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 10 mg/kg
SEX/DURATION            : female 12-21 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   AJPHAP American Journal of Physiology.  (American Physiological Soc., 9650
   Rockville Pike, Bethesda, MD 20814)  V.1-    1898- Volume(issue)/page/year:
   180,296,1955
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 5 mg/kg
SEX/DURATION            : female 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
   AJPHAP American Journal of Physiology.  (American Physiological Soc., 9650
   Rockville Pike, Bethesda, MD 20814)  V.1-    1898- Volume(issue)/page/year:
   180,47,1955
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1250 ug/kg
SEX/DURATION            : female 5 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   AJPHAP American Journal of Physiology.  (American Physiological Soc., 9650
   Rockville Pike, Bethesda, MD 20814)  V.1-    1898- Volume(issue)/page/year:
   180,47,1955
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1250 ug/kg
SEX/DURATION            : female 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   AJPHAP American Journal of Physiology.  (American Physiological Soc., 9650
   Rockville Pike, Bethesda, MD 20814)  V.1-    1898- Volume(issue)/page/year:
   179,301,1954
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 30 mg/kg
SEX/DURATION            : female 3-5 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   JRPFA4 Journal of Reproduction and Fertility.  (Biochemical Soc. Book Depot,
   POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK)  V.1-    1960-
   Volume(issue)/page/year: 18,81,1969
 
                            *** END OF RECORD ***