*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : KE7700000
CHEMICAL NAME : Ergotamine
CAS REGISTRY NUMBER : 113-15-5
BEILSTEIN REFERENCE NO. : 0078890
REFERENCE : 4-25-00-00964 (Beilstein Handbook Reference)
LAST UPDATED : 199709
DATA ITEMS CITED : 13
MOLECULAR FORMULA : C33-H35-N5-O5
MOLECULAR WEIGHT : 581.73
WISWESSER LINE NOTATION : T C6656 1A P GN LM CUTT&&J G1 EVM- DT B565 CO EVN
HVNTJ BQ D1 G1R
COMPOUND DESCRIPTOR : Drug
Human
SYNONYMS/TRADE NAMES :
* Ergotaman-3',6',18-trione, 12'-hydroxy-2'-methyl-5'-(phenylmethyl)-,
(5'-alpha)-
* Ergotamin
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Human - infant
DOSE/DURATION : 4400 ug/kg/4D-I
TOXIC EFFECTS :
Vascular - regional or general arteriolar constriction
REFERENCE :
KLWOAZ Klinische Wochenscrift. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.1- 1922- Volume(issue)/page/year:
9,258,1930
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Human
DOSE/DURATION : 171 ug/kg/17D-I
TOXIC EFFECTS :
Musculoskeletal - changes in teeth and supporting structures
Skin and Appendages - corrosive (after topical exposure)
REFERENCE :
MMWOAU Muenchener Medicinische Wochenschrift. (Munich, Fed. Rep. Ger.)
V.33-115, 1886-1973. Volume(issue)/page/year: 80,1784,1933
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Human - man
DOSE/DURATION : 3570 ng/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
HXPHAU Handbuch der Experimentellen Pharmakologie. (Berlin, Ger.) New
series: V.1-49, 1935-78. For publisher information, see HEPHD2.
Volume(issue)/page/year: 6,107,1938
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 100 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - respiratory stimulation
Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849-
Volume(issue)/page/year: 119,1302,1935
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 80 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SMWOAS Schweizerische Medizinische Wochenschrift. (Schwabe & Co.,
Steintorst 13, 4010 Basel, Switzerland) V.50- 1920-
Volume(issue)/page/year: 76,1254,1946
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 52 mg/kg
TOXIC EFFECTS :
Behavioral - ataxia
Cardiac - pulse rate increase, without fall in BP
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du Systeme
Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948
Volume(issue)/page/year: -,285,1948
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HXPHAU Handbuch der Experimentellen Pharmakologie. (Berlin, Ger.) New
series: V.1-49, 1935-78. For publisher information, see HEPHD2.
Volume(issue)/page/year: 6,103,1938
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 11 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SMWOAS Schweizerische Medizinische Wochenschrift. (Schwabe & Co.,
Steintorst 13, 4010 Basel, Switzerland) V.50- 1920-
Volume(issue)/page/year: 76,1254,1946
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 3 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SMWOAS Schweizerische Medizinische Wochenschrift. (Schwabe & Co.,
Steintorst 13, 4010 Basel, Switzerland) V.50- 1920-
Volume(issue)/page/year: 76,1254,1946
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Bird - chicken
DOSE/DURATION : 2400 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 179,115,1935
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Bird - chicken
DOSE/DURATION : 2 gm/kg
TOXIC EFFECTS :
Behavioral - ataxia
Lungs, Thorax, or Respiration - cyanosis
Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849-
Volume(issue)/page/year: 119,1302,1935
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Amphibian - frog
DOSE/DURATION : 33 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 27,459,1923
*** REVIEWS ***
TOXICOLOGY REVIEW
ADVPA3 Advances in Pharmacology. (New York, NY) V.1-6, 1962-68. For
publisher information, see AVPCAQ. Volume(issue)/page/year: 4,263,1966
*** END OF RECORD ***