*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : KE5250000
CHEMICAL NAME           : Ergoline-8-beta-carboxamide,
                          9,10-didehydro-N-((S)-2-hydroxy-1-methylethyl)-6-meth
                          yl-, maleate (1:1) (salt)
CAS REGISTRY NUMBER     : 129-51-1
LAST UPDATED            : 199707
DATA ITEMS CITED        : 11
MOLECULAR FORMULA       : C19-H23-N3-O2.C4-H4-O4
MOLECULAR WEIGHT        : 441.53
WISWESSER LINE NOTATION : T C6656 1A P GN LM CUTT&&J EVMY1&1Q G1 &OV1U1VO
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
                          Reproductive Effector
                          Human
                          Natural Product
SYNONYMS/TRADE NAMES :
   * Cornocentin
   * Crude ergot
   * Ergomet
   * Ergometrine acid maleate
   * Ergometrine maleate
   * Ergonovine, maleate (1:1) (salt)
   * D-Ergonovine maleate
   * Ergotocin maleate
   * Ergotrate
   * Ermetrin
   * Oxytocic
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Human - infant
DOSE/DURATION           : 40 ug/kg
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   JAMAAP JAMA, Journal of the American Medical Association.  (AMA, 535 N.
   Dearborn St., Chicago, IL 60610)  V.1-    1883-  Volume(issue)/page/year:
   250,729,1983
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 15 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M.,
   Springfield, IL, C.C. Thomas, 1970  Volume(issue)/page/year: 2,73,1970
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 8260 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   23,537,1972
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 80 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Skin and Appendages - hair
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 54,398,1935
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 140 mg/kg/4W-C
TOXIC EFFECTS :
   Liver - changes in liver weight
   Endocrine - hypoglycemia
   Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.20-    1982- Volume(issue)/page/year:
   34,951,1996
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 669 gm/kg/96W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Sense Organs and Special Senses (Ear) - effect, not otherwise specified
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   2,11,1942
 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 773 gm/kg/44W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Sense Organs and Special Senses (Ear) - effect, not otherwise specified
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   2,11,1942
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 100 mg/kg
SEX/DURATION            : lactating female 5 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   ENDOAO Endocrinology (Baltimore).  (Williams & Wilkins Co., 428 E. Preston
   St., Baltimore, MD 21203) V.1-    1917-  Volume(issue)/page/year:
   90,285,1972
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 10 nmol/L
REFERENCE :
   TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis.  (Alan R. Liss, Inc.,
   41 E. 11th St., New York, NY 10003)  V.1-    1980- Volume(issue)/page/year:
   8,169,1988

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 83984
       No. of Facilities: 33 (estimated)
       No. of Industries: 1
       No. of Occupations: 2
       No. of Employees: 363 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 83984
       No. of Facilities: 179 (estimated)
       No. of Industries: 1
       No. of Occupations: 6
       No. of Employees: 3249 (estimated)
       No. of Female Employees: 1902 (estimated)

 
                            *** END OF RECORD ***