*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : KD1576000
CHEMICAL NAME           : 2,7-(Epoxypentadeca(1,11,13)trienimino)benzofuro(4,5-
                          e)pyrido(1,2-a)benzim idazole-1,15(2H)- dione,
                          25-(acetyloxy)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,
                          11,16,20,22,24,26-oct amethyl-,
                          (2S-(2R*,16Z,18E,20R*,21R*,22S*,23S*,24S*,25R*,26S*,2
                          7R*,28E))-
CAS REGISTRY NUMBER     : 80621-81-4
BEILSTEIN REFERENCE NO. : 3584528
LAST UPDATED            : 199704
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C43-H51-N3-O11
MOLECULAR WEIGHT        : 785.97
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 4-Deoxy-4'-methylpyrido(1',2'-1,2)imidazo(5,4-c)rifamycin SV
   * Fatroximin
   * L 105
   * L 105 (Ansamacrolide antibiotic)
   * L 105SV
   * Normix
   * Rifacol
   * Rifamycin L 105
   * Rifamycin L 105SV
   * Rifaxidin
   * Rifaximin
   * Ritacol
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CHEMEV Chemioterapia.  (Tipografia "Il Sedicesimo", Via Manneli 29r, 50136
   Florence, Italy) V.1-7,  1982-88.  Volume(issue)/page/year: 5,263,1986
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year:
   7,260,1982
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 9 gm/kg/26W-I
TOXIC EFFECTS :
   Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
   CHEMEV Chemioterapia.  (Tipografia "Il Sedicesimo", Via Manneli 29r, 50136
   Florence, Italy) V.1-7,  1982-88.  Volume(issue)/page/year: 5,263,1986
 
                            *** END OF RECORD ***