*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : KD1575000 CHEMICAL NAME : 2,7-(Epoxypentadeca(1,11,13)trienimino)benzofuro(4,5- a)phenazine-1,15(2H)- dione, 5,6,21,23,25-pentahydroxy-27-methoxy-2,4,16,20,22,24, 26-heptamethyl-, 25-acetate CAS REGISTRY NUMBER : 10238-70-7 BEILSTEIN REFERENCE NO. : 0956463 LAST UPDATED : 199703 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C43-H49-N3-O11 MOLECULAR WEIGHT : 783.95 WISWESSER LINE NOTATION : T J6 H6 E6 B65-25- A C D 2BE O& AV EN LN TO VO N&VM WU I&U J&U L&U&&&TTTJ OQ QQ R1 U1 B&O1 C& SYNONYMS/TRADE NAMES : * Rifazine *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CMTRAG Chemotherapia. (Basel, Switzerland) V.1-12, 1960-67. For publisher information, see CHTHBK. Volume(issue)/page/year: 12,247,1967 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1638 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CMTRAG Chemotherapia. (Basel, Switzerland) V.1-12, 1960-67. For publisher information, see CHTHBK. Volume(issue)/page/year: 12,247,1967 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 291 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CMTRAG Chemotherapia. (Basel, Switzerland) V.1-12, 1960-67. For publisher information, see CHTHBK. Volume(issue)/page/year: 12,247,1967 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 27 gm/kg/18W-I TOXIC EFFECTS : Liver - other changes Skin and Appendages - hair Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : CMTRAG Chemotherapia. (Basel, Switzerland) V.1-12, 1960-67. For publisher information, see CHTHBK. Volume(issue)/page/year: 12,247,1967 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 10800 mg/kg/18W-I TOXIC EFFECTS : Liver - other changes Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases REFERENCE : CMTRAG Chemotherapia. (Basel, Switzerland) V.1-12, 1960-67. For publisher information, see CHTHBK. Volume(issue)/page/year: 12,247,1967 *** END OF RECORD ***