*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : KD4170000
CHEMICAL NAME           : 3,12-Epoxy-12H-pyranol(4,3-j)-1,2-benzodioxepin-10(3H
                          )-one, octahydro-3,6,9-trimethyl-, (3-
                          alpha,5a-beta,6-beta,8a-beta,9-alpha,12-beta,12aR*)-(
                          +)-
CAS REGISTRY NUMBER     : 63968-64-9
BEILSTEIN REFERENCE NO. : 4194670
LAST UPDATED            : 199612
DATA ITEMS CITED        : 9
MOLECULAR FORMULA       : C15-H22-O5
MOLECULAR WEIGHT        : 282.37
COMPOUND DESCRIPTOR     : Drug
                          Natural Product
SYNONYMS/TRADE NAMES :
   * Arteannuin
   * Artemisia annua L., extract
   * Artemisine
   * Artemisinin
   * Huanghuahaosu
   *   Octahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin
     -10(3H)-one
   * Qinghaosu
   * Qing Hau Sau
   * Qing Hau SU
   * Qinghosu
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5576 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - tremor
   Behavioral - ataxia
REFERENCE :
   JTCMEC Journal of Traditional Chinese Medicine (English Edition). (All-China
   Assoc. of Traditional Chinese Medicine, Academy of Traditional Chinese
   Medicine)  V.1-    1981-  Volume(issue)/page/year: 2,31,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2571 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - tremor
   Behavioral - ataxia
REFERENCE :
   JTCMEC Journal of Traditional Chinese Medicine (English Edition). (All-China
   Assoc. of Traditional Chinese Medicine, Academy of Traditional Chinese
   Medicine)  V.1-    1981-  Volume(issue)/page/year: 2,31,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4228 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - tremor
   Behavioral - ataxia
REFERENCE :
   JTCMEC Journal of Traditional Chinese Medicine (English Edition). (All-China
   Assoc. of Traditional Chinese Medicine, Academy of Traditional Chinese
   Medicine)  V.1-    1981-  Volume(issue)/page/year: 2,31,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1558 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CMJODS Chinese Medical Journal (Beijing, English Edition).  (China
   International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 
     1975-    Adopted vol. no. 92 in 1979.  Volume(issue)/page/year:
   92,811,1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CMJODS Chinese Medical Journal (Beijing, English Edition).  (China
   International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 
     1975-    Adopted vol. no. 92 in 1979.  Volume(issue)/page/year:
   92,811,1979
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AMACCQ Antimicrobial Agents and Chemotherapy.  (American Soc. for
   Microbiology, 1913 I St., NW, Washington, DC 20006)  V.1-    1972-
   Volume(issue)/page/year: 37,1108,1993
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >800 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   JTCMEC Journal of Traditional Chinese Medicine (English Edition). (All-China
   Assoc. of Traditional Chinese Medicine, Academy of Traditional Chinese
   Medicine)  V.1-    1981-  Volume(issue)/page/year: 2,31,1982
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3200 mg/kg/4D-I
TOXIC EFFECTS :
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - transaminases
REFERENCE :
   CTYAD8 Zhongcaoyao.  Chinese Traditional and Herbal Medicine.  (China
   International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11-
      1980-  Volume(issue)/page/year: 21,134,1990
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 1344 mg/kg/14D-I
TOXIC EFFECTS :
   Cardiac - other changes
   Blood - changes in bone marrow (not otherwise specified)
   Blood - other changes
REFERENCE :
   JTCMEC Journal of Traditional Chinese Medicine (English Edition). (All-China
   Assoc. of Traditional Chinese Medicine, Academy of Traditional Chinese
   Medicine)  V.1-    1981-  Volume(issue)/page/year: 2,31,1982
 
                            *** END OF RECORD ***